The Influence of High-Impact Exercise on Cortical and Trabecular Bone Mineral Content and 3D Distribution Across the Proximal Femur in Older Men: A Randomized Controlled Unilateral Intervention
The Influence of High-Impact Exercise on Cortical and Trabecular Bone Mineral Content and 3D Distribution Across the Proximal Femur in Older Men: A Randomized Controlled Unilateral Intervention
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DOI：
10.1002/jbmr.2499
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发表时间：
2015-09-01
影响因子：
6.2
通讯作者：
Brooke-Wavell, Katherine
中科院分区：
文献类型：
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作者：
Allison, Sarah J.;Poole, Kenneth E. S.;Brooke-Wavell, Katherine
尽管运动对骨矿物质含量 (BMC) 的影响不大，但经常锻炼的人骨折风险较低。运动可能会产生局部皮质骨和骨小梁的变化，从而影响骨强度，而与 BMC 无关。我们之前证明，与老年男性的对照腿相比，每天进行简短的单侧跳跃练习可以增加锻炼腿的股骨颈 BMC。本研究使用临床 CT 评估了这些练习对皮质骨和小梁骨及其在股骨近端的 3D 分布的影响。 50 名健康男性在运动干预前后进行了盆腔 CT 扫描。我们使用髋部 QCT 分析来量化传统感兴趣区域的 BMC 并估计生物力学变量。皮质骨映射定位了每个近端股骨的局部皮质块表面密度和皮质内小梁密度的变化，这涉及到规范的近端股骨模型的注册。在统计参数映射之后，我们可视化并量化了两条腿中变量随时间的统计显着变化以及腿之间的显着差异。 34 名平均年龄 (SD) 70 (4) 岁的男性锻炼了 12 个月，参加了 92% 的规定训练。在传统的感兴趣区域，双腿的皮质和小梁 BMC 随着时间的推移而增加。运动中转子处的皮质 BMC 比对照腿增加更多，而股骨颈屈曲比在运动中比对照腿下降更多。在整个股骨近端，股骨颈和前轴的前部和后部皮质质量表面密度随着运动而显着增加（2.7％；p6％）。皮质内小梁密度也增加（6.4%；股骨前部、转子和下股骨头的 p12%。奇怪的冲击运动增加了可能对结构完整性很重要的区域的皮质块表面密度和皮质内小梁密度。这些运动引起的变化是局部的，而不是均匀分布在近端股骨上。(c) 2015 年美国骨与矿物质研究学会。
Regular exercisers have lower fracture risk, despite modest effects of exercise on bone mineral content (BMC). Exercise may produce localized cortical and trabecular bone changes that affect bone strength independently of BMC. We previously demonstrated that brief, daily unilateral hopping exercises increased femoral neck BMC in the exercise leg versus the control leg of older men. This study evaluated the effects of these exercises on cortical and trabecular bone and its 3D distribution across the proximal femur, using clinical CT. Fifty healthy men had pelvic CT scans before and after the exercise intervention. We used hip QCT analysis to quantify BMC in traditional regions of interest and estimate biomechanical variables. Cortical bone mapping localized cortical mass surface density and endocortical trabecular density changes across each proximal femur, which involved registration to a canonical proximal femur model. Following statistical parametric mapping, we visualized and quantified statistically significant changes of variables over time in both legs, and significant differences between legs. Thirty-four men aged mean (SD) 70 (4) years exercised for 12-months, attending 92% of prescribed sessions. In traditional regions of interest, cortical and trabecular BMC increased over time in both legs. Cortical BMC at the trochanter increased more in the exercise than control leg, whereas femoral neck buckling ratio declined more in the exercise than control leg. Across the entire proximal femur, cortical mass surface density increased significantly with exercise (2.7%; p6%) at anterior and posterior aspects of the femoral neck and anterior shaft. Endocortical trabecular density also increased (6.4%; p12% at the anterior femoral neck, trochanter, and inferior femoral head. Odd impact exercise increased cortical mass surface density and endocortical trabecular density, at regions that may be important to structural integrity. These exercise-induced changes were localized rather than being evenly distributed across the proximal femur. (c) 2015 American Society for Bone and Mineral Research.