A positive impact on the serum lipid profile and cytokines after the consumption of a plant sterol-enriched beverage with a milk fat globule membrane: a clinical study
A positive impact on the serum lipid profile and cytokines after the consumption of a plant sterol-enriched beverage with a milk fat globule membrane: a clinical study
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DOI：
10.1039/c8fo00353j
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发表时间：
2018-10-01
期刊：
影响因子：
6.1
通讯作者：
Garcia-Llatas, Guadalupe
中科院分区：
文献类型：
--
作者：
Alvarez-Sala, Andrea;Blanco-Morales, Virginia;Garcia-Llatas, Guadalupe
采用随机、双盲、交叉、多次给药的生物利用度研究方法，评价了食用含乳脂球膜的乳基水果饮料后，膳食中植物类固醇(PS)摄入、胆固醇前体和细胞因子的降胆固醇作用及其对血清生物标志物的影响。绝经后妇女(n=38)在每个研究期间的6周内每天摄入250毫升添加或不添加2克PS的饮料。随着添加PS的饮料的摄入，血清总胆固醇(治疗前：220.0+/-27.8vs治疗后：212.9+/-25.8p<0.05)和低密度脂蛋白-胆固醇(129.4+/-28.5vs.121.7+/-24.4p<0.05)显著降低。胆固醇前体Lathosterol(11.2%)、膳食PS摄入量的标志物(菜籽固醇43.1%和-谷甾醇32.5%)和抗炎IL-10细胞因子(22.5%)显著增加，而促炎IL-1(6.7%)显著降低。未检测到高密度脂蛋白-胆固醇、其他甾醇(桥本甾醇和豆甾醇)或细胞因子(IL-6、IL-8、IL-12p70和肿瘤坏死因子-α)的变化。这些结果表明，这种富含PS的奶基水果饮料适合在临床干预期间使用，而且由于观察到胆固醇水平的显著降低，饮用这种饮料可能是改善PS功能的一种足够的方式。因此，服用该饮料有助于降低心血管疾病的风险，并对绝经后妇女的血清炎症状态产生有益的影响。
The hypocholesterolemic effect and the modification of serum biomarkers of a dietary plant sterol (PS) intake, cholesterol precursors and cytokines after the consumption of milk-based fruit beverages with a milk fat globule membrane were evaluated by a randomized, double-blind, crossover, multiple dose bioavailability study. Postmenopausal women (n = 38) consumed daily 250 mL of a beverage with or without 2 g of PS added during 6 weeks in each of the study periods. With the intake of the PS-added beverage, significant decreases (mg dL(-1)) in serum total cholesterol (pre-treatment: 220.0 +/- 27.8 vs. post-treatment: 212.9 +/- 25.8; p < 0.05) and LDL-cholesterol (129.4 +/- 28.5 vs. 121.7 +/- 24.4; p < 0.05) were detected. The cholesterol precursor lathosterol (11.2%), markers of the dietary PS intake (campesterol 43.1% and -sitosterol 32.5%), and anti-inflammatory IL-10 cytokine (22.5%) increased significantly, with a concomitant significant reduction in pro-inflammatory IL-1 (6.7%). No variations in HDL-cholesterol, other sterols (desmosterol and stigmasterol) or cytokines (IL-6, IL-8, IL-12p70 and TNF-) were detected. These results indicated that this kind of PS-enriched milk-based fruit beverage is suitable during the period of clinical intervention, and its consumption may be an adequate way to improve PS functionality since a significant reduction in cholesterol levels has been observed. Therefore, the intake of this beverage could contribute to reduce the risk of cardiovascular disease also obtaining a beneficial effect on the serum inflammatory status in postmenopausal women.