Low-dose X-ray depilatory treatment induces trichoblastic tumors of the scalp
Low-dose X-ray depilatory treatment induces trichoblastic tumors of the scalp
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DOI：
10.1159/000107623
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发表时间：
2007-01-01
期刊：
影响因子：
3.4
通讯作者：
Kamoun, M. R.
中科院分区：
文献类型：
--
作者：
Fazaa, B.;Cribier, B.;Kamoun, M. R.
背景：在抗真菌药物出现之前，脱毛性放射治疗主要用于癣病。接受这种治疗的患者患头皮肿瘤或其他癌症的风险很高。本研究的目的是描述X射线治疗癣后发生的头皮肿瘤。研究方法：我们纳入了1988年至2001年期间在突尼斯查尔斯尼科勒医院皮肤科记录的放射治疗后头皮肿瘤病例。我们记录了临床描述，并将所有病例重新提交进行显微镜分析。结果：61例肿瘤发生在33名男性和12名女性，平均年龄49.8岁。21%的患者出现放射性皮炎。基底细胞癌47例，毛母细胞瘤10例，毛母细胞癌4例。12例患者有2-5个肿瘤，其中3例合并肿瘤类型。放射治疗后肿瘤发病的平均延迟在基底细胞癌病例中为39.4年，在毛母细胞瘤病例中为38.3年，在毛母细胞癌病例中为35.6年。结论：尽管基底细胞癌是这种情况下最常见的肿瘤，但毛母细胞瘤也很常见。我们描述，为第一次，辐射诱导的毛细胞癌。毛母细胞肿瘤还没有在这方面的描述，因为这个概念是相对较新的。版权所有（C）2007 S. Karger AG，巴塞尔。
Background: Depilatory radiotherapy for ringworm was largely used before antifungals were available. Patients who underwent this treatment are at high risk of developing scalp tumors or other cancers. The aim of this study was to characterize scalp tumors occurring after X-ray therapy for ringworm. Methods: We included cases of postradiotherapy scalp tumors recorded at the Dermatology Department of the Charles Nicolle Hospital, Tunis between 1988 and 2001. We recorded clinical descriptions and all cases were resubmitted to microscopic analysis. Results: Sixty-one tumors occurred in 33 men and 12 women with a mean age of 49.8 years. Radiodermatitis was present in 21% of patients. Tumors were basal cell carcinomas in 47 cases, trichoblastomas in 10 cases and trichoblastic carcinomas in 4 cases. Twelve patients had 2-5 tumors, with combinations of tumor types in 3 of them. Mean delay of onset of tumors after radiotherapy was 39.4 years in basal cell carcinoma cases, 38.3 years in trichoblastoma cases and 35.6 years in trichoblastic carcinoma cases. Conclusions: This series shows that although basal cell carcinoma is the most frequent tumor in this situation, trichoblastomas are common. We describe, for the first time, radio-induced trichoblastic carcinomas. Trichoblastic tumors have not yet been described in this context because this concept is relatively recent. Copyright (C) 2007 S. Karger AG, Basel.