MODIFIED METABOLIC RESPONSIVENESS TO GLUCAGON IN COLD-ACCLIMATED AND HEAT-ACCLIMATED RATS
MODIFIED METABOLIC RESPONSIVENESS TO GLUCAGON IN COLD-ACCLIMATED AND HEAT-ACCLIMATED RATS
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DOI：
10.1016/0024-3205(82)90614-2
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发表时间：
1982-01-01
期刊：
影响因子：
6.1
通讯作者：
KUROSHIMA, A
中科院分区：
文献类型：
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作者：
DOI, K;KUROSHIMA, A
在未麻醉和无约束的热对照（WC）、冷习服（CA）和热习服（HA）大鼠中研究胰高血糖素对全身氧消耗和肩胛间棕色脂肪组织（BAT）的产热效应。胰高血糖素使各实验组的耗氧量、体温和BAT温度显著升高。与WC相比，CA中对胰高血糖素的这种增加的产热反应显著增强，HA中降低。BAT对去甲肾上腺素的产热反应也类似于对胰高血糖素的反应;在CA中增强，在HA中降低。胰高血糖素在温度适应中作为产热激素，至少部分通过其对BAT的作用，起到体温调节的非颤抖性产热作用。
Calorigenic effect of glucagon on whole body O2 consumption and interscapular brown adipose tissue (BAT) was investigated in unanesthetized and unrestrained warm controls (WC), cold-acclimated rats (CA) and heat-acclimated rats (HA). Glucagon produced significant elevation of O2 consumption, body temperature and BAT temperature in all experimental groups. Such increased calorigenic responses to glucagon were significantly potentiated in CA and reduced in HA compared with those in WC. Thermogenic response of BAT to norepinephrine was also similar to that to glucagon; it was potentiated in CA, reduced in HA. Glucagon would serve thermoregulatory nonshivering thermogenesis in temperature acclimation as calorigenic hormone, at least in part, through its action on BAT.