Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches.
Critical signaling pathways governing hepatocellular carcinoma behavior; small molecule-based approaches.
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DOI：
10.1186/s12935-021-01924-w
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发表时间：
2021-04-13
影响因子：
5.8
通讯作者：
Farzaneh M
中科院分区：
文献类型：
--
作者：
Farzaneh Z;Vosough M;Agarwal T;Farzaneh M
肝细胞癌（HCC）是癌症导致的第二大死亡原因。虽然有不同的治疗选择，但这些策略在限制肿瘤细胞的增殖和转移方面并不有效。肝肿瘤微环境中含有对HCC的癌表型具有支持或抑制作用的非实质细胞。几种信号通路在HCC中失调并导致肝癌细胞的不受控制的细胞增殖、转移和复发。最近的研究已经建立了使用小分子预防和治疗HCC的新方法。小分子化合物是指分子量较小的化合物，通常抑制信号转导途径中的特定靶点。这些组分可以诱导细胞周期停滞、凋亡、阻断转移和肿瘤生长。设计同时靶向HCC和非实质性肿瘤人群的策略可能会导致更多相关的研究结果。这些策略可能为治疗HCC开辟新的途径，对健康细胞的细胞毒性作用最小。这项研究提供了关于控制HCC行为的关键信号通路以及在体外和体内模型中使用小分子控制HCC的最新发现。
Hepatocellular carcinoma (HCC) is the second leading cause of death due to cancer. Although there are different treatment options, these strategies are not efficient in terms of restricting the tumor cell’s proliferation and metastasis. The liver tumor microenvironment contains the non-parenchymal cells with supportive or inhibitory effects on the cancerous phenotype of HCC. Several signaling pathways are dis-regulated in HCC and cause uncontrolled cell propagation, metastasis, and recurrence of liver carcinoma cells. Recent studies have established new approaches for the prevention and treatment of HCC using small molecules. Small molecules are compounds with a low molecular weight that usually inhibit the specific targets in signal transduction pathways. These components can induce cell cycle arrest, apoptosis, block metastasis, and tumor growth. Devising strategies for simultaneously targeting HCC and the non-parenchymal population of the tumor could lead to more relevant research outcomes. These strategies may open new avenues for the treatment of HCC with minimal cytotoxic effects on healthy cells. This study provides the latest findings on critical signaling pathways governing HCC behavior and using small molecules in the control of HCC both in vitro and in vivo models.
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影响因子：
4.7
作者：
Fabregat I;Caballero-Díaz D
通讯作者：
Caballero-Díaz D
影响因子：
3.9
作者：
Azer SA
通讯作者：
Azer SA
影响因子：
4.3
作者：
Cardin, Romilda;Piciocchi, Marika;Farinati, Fabio
通讯作者：
Farinati, Fabio
影响因子：
11.5
作者：
Banerjee S;Biehl A;Gadina M;Hasni S;Schwartz DM
通讯作者：
Schwartz DM
DOI：
10.1002/hep.29496
发表时间：
2018-03
期刊：
Hepatology (Baltimore, Md.)
影响因子：
--
作者：
Bouattour M;Raymond E;Qin S;Cheng AL;Stammberger U;Locatelli G;Faivre S
通讯作者：
Faivre S