Respiratory modulation of human autonomic rhythms
Respiratory modulation of human autonomic rhythms
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DOI：
10.1152/ajpheart.2001.280.6.h2674
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发表时间：
2001-06-01
影响因子：
4.8
通讯作者：
Eckberg, DL
中科院分区：
文献类型：
--
作者：
Badra, LJ;Cooke, WH;Eckberg, DL
我们研究了三种类型的呼吸（自主呼吸、频率控制呼吸（0.25 Hz）和 100% 氧气过度通气）和呼吸暂停对 9 名健康年轻人的 R-R 间期、光电体积描记动脉压和肌肉交感节律的影响。我们集成了低频率（0.05-0.15 Hz）和呼吸频率（0.15-0.3 Hz）的快速傅里叶变换功率谱；使用交叉频谱技术估计低频迷走神经压力感受器-心脏反射增益；并使用部分相干分析来消除呼吸对 R-R 间期、收缩压和肌肉交感神经谱的影响。信号之间的相干性随着频率和时间的函数而变化。部分化消除了这些信号在呼吸时的一致性，但在低频时却没有。呼吸模式不会影响低频振荡，并且它们在呼吸暂停期间持续存在。我们的研究记录了低频节律与呼吸活动的独立性，并表明呼吸频率下动脉压、R-R间期和肌肉交感神经活动之间可能存在的密切相关性是由于呼吸对这些指标的影响而不是动脉压力反射生理学造成的。最重要的是，我们的结果表明，自主神经节律和血流动力学节律之间的相关性随着时间和频率的变化而变化，因此是兼性的而不是固定的。
We studied the influence of three types of breathing [spontaneous, frequency controlled (0.25 Hz), and hyperventilation with 100% oxygen] and apnea on R-R interval, photoplethysmographic arterial pressure, and muscle sympathetic rhythms in nine healthy young adults. We integrated fast Fourier transform power spectra over low (0.05-0.15 Hz) and respiratory (0.15-0.3 Hz) frequencies; estimated vagal baroreceptor-cardiac reflex gain at low frequencies with cross-spectral techniques; and used partial coherence analysis to remove the influence of breathing from the R-R interval, systolic pressure, and muscle sympathetic nerve spectra. Coherence among signals varied as functions of both frequency and time. Partialization abolished the coherence among these signals at respiratory but not at low frequencies. The mode of breathing did not influence low-frequency oscillations, and they persisted during apnea. Our study documents the independence of low-frequency rhythms from respiratory activity and suggests that the close correlations that may exist among arterial pressures, R-R intervals, and muscle sympathetic nerve activity at respiratory frequencies result from the influence of respiration on these measures rather than from arterial baroreflex physiology. Most importantly, our results indicate that correlations among autonomic and hemodynamic rhythms vary over time and frequency, and, thus, are facultative rather than fixed.