Psychological stress during exercise: immunoendocrine and oxidative responses
Psychological stress during exercise: immunoendocrine and oxidative responses
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DOI：
10.1258/ebm.2010.010176
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发表时间：
2010-12-01
影响因子：
3.2
通讯作者：
Acevedo, Edmund O.
中科院分区：
文献类型：
--
作者：
Huang, Chun-Jung;Webb, Heather E.;Acevedo, Edmund O.
本研究的目的是研究暴露于双重挑战（生理和心理压力）的健康个体中儿茶酚胺（肾上腺素[EPI]和去甲肾上腺素[NE]）、白细胞介素-2 （IL-2）和氧化应激生物标志物（8-异前列腺素）的变化。此外，本研究还研究了儿茶酚胺（NE和EPI）和8-异前列腺素之间以及IL-2和8-异前列腺素之间在生理和心理双重挑战后可能存在的关系。7名健康男性受试者完成了两个实验条件。单独运动条件（EAC）包括以60% VO（2max）骑车37分钟，而双重应激条件（DSC）包括骑车20分钟的精神挑战。DSC显示EPI和8-异前列腺素水平升高（时间相互作用显著）。NE和IL-2在两种情况下均随时间发生显著变化。此外，在双重应激下，EPI曲线下面积（AUC）与NE AUC和IL-2 AUC呈正相关。在双重胁迫下，NE AUC与IL-2 AUC和8-异前列腺素峰呈正相关，IL-2峰与8-异前列腺素峰呈正相关。双重应激期间氧化应激升高的潜在解释可能是通过儿茶酚胺和IL-2释放的影响。这些发现可能进一步提供了双重压力改变包括消防、军事行动和执法在内的许多职业的生理稳态的潜在解释。更好地了解这些对压力的反应有助于找到策略（例如运动训练），以克服与身体和精神要求高的职业相关的固有心理生物学挑战。
The purpose of this study was to examine the changes in catecholamines (epinephrine [EPI] and norepinephrine [NE]), interleukin-2 (IL-2) and a biomarker of oxidative stress (8-isoprostane) in healthy individuals who were exposed to a dual challenge (physical and psychological stress). Furthermore, this study also examined the possible relationships between catecholamines (NE and EPI) and 8-isoprostane and between IL-2 and 8-isoprostane following a combined physical and psychological challenge. Seven healthy male subjects completed two experimental conditions. The exercise-alone condition (EAC) consisted of cycling at 60% VO(2max) for 37 min, while the dual-stress condition (DSC) included 20 min of a mental challenge while cycling. DSC showed greater EPI and 8-isoprostane levels (significant condition by time interaction). NE and IL-2 revealed significant change across time in both conditions. In addition, following dual stress, EPI area-under-the-curve (AUC) demonstrated a positive correlation with NE AUC and IL-2 AUC. NE AUC was positively correlated with IL-2 AUC and peak 8-isoprostane, and peak IL-2 was positively correlated with peak 8-isoprostane in response to a dual stress. The potential explanation for elevated oxidative stress during dual stress may be through the effects of the release of catecholamines and IL-2. These findings may further provide the potential explanation that dual stress alters physiological homeostasis in many occupations including firefighting, military operations and law enforcement. A greater understanding of these responses to stress can assist in finding strategies (e.g. exercise training) to overcome the inherent psychobiological challenges associated with physically and mentally demanding professions.