Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood.
Early Life Short-Term Exposure to Polychlorinated Biphenyl 126 in Mice Leads to Metabolic Dysfunction and Microbiota Changes in Adulthood.
复制标题
DOI：
10.3390/ijms23158220
复制
发表时间：
2022-07-26
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
生命早期接触环境污染物可能会对以后的健康产生长期后果和有害影响。在这里，我们利用 16S rRNA 基因测序、宏基因组学以及基于 1H NMR 和质谱的代谢组学，研究了小鼠生命早期接触 3,3',4,4',5-五氯联苯 (PCB 126)（24 μg/kg 体重，持续五天）对宿主和肠道微生物群的短期和长期影响。在 PCB 126 暴露后 6 天和 13 周观察到芳烃受体 (AHR) 响应基因 Cyp1a1 的诱导，这与 PCB 126 的长半衰期一致。生命早期，短期 PCB 126 暴露导致成年期代谢异常，包括肝脏氨基酸和核苷酸代谢以及胆汁酸代谢和肝脏脂肪生成增加的变化。有趣的是，生命早期接触 PCB 126 对成年期细菌的群落结构、代谢和功能水平有更大的影响。这项研究为生命早期环境污染物暴露与晚年代谢紊乱风险增加之间的关联提供了证据，并表明微生物组是环境化学物质暴露的关键目标。
Early life exposure to environmental pollutants may have long-term consequences and harmful impacts on health later in life. Here, we investigated the short- and long-term impact of early life 3,3′,4,4′,5-pentacholorobiphenyl (PCB 126) exposure (24 μg/kg body weight for five days) in mice on the host and gut microbiota using 16S rRNA gene sequencing, metagenomics, and 1H NMR- and mass spectrometry-based metabolomics. Induction of Cyp1a1, an aryl hydrocarbon receptor (AHR)-responsive gene, was observed at 6 days and 13 weeks after PCB 126 exposure consistent with the long half-life of PCB 126. Early life, Short-Term PCB 126 exposure resulted in metabolic abnormalities in adulthood including changes in liver amino acid and nucleotide metabolism as well as bile acid metabolism and increased hepatic lipogenesis. Interestingly, early life PCB 126 exposure had a greater impact on bacteria in adulthood at the community structure, metabolic, and functional levels. This study provides evidence for an association between early life environmental pollutant exposure and increased risk of metabolic disorders later in life and suggests the microbiome is a key target of environmental chemical exposure.
登录
查看更多内容
影响因子：
9.2
作者：
Cai YY;Huang FQ;Lao X;Lu Y;Gao X;Alolga RN;Yin K;Zhou X;Wang Y;Liu B;Shang J;Qi LW;Li J
通讯作者：
Li J
影响因子：
4.2
作者：
Metges, CC
通讯作者：
Metges, CC
影响因子：
7.3
作者：
Matsuura M
通讯作者：
Matsuura M
影响因子：
7.7
作者：
Beghini F;McIver LJ;Blanco-Míguez A;Dubois L;Asnicar F;Maharjan S;Mailyan A;Manghi P;Scholz M;Thomas AM;Valles-Colomer M;Weingart G;Zhang Y;Zolfo M;Huttenhower C;Franzosa EA;Segata N
通讯作者：
Segata N
影响因子：
4.5
作者：
Di Paolo, Carolina;Groh, Ksenia J.;Schirmer, Kristin
通讯作者：
Schirmer, Kristin