Clinical Features and Prognosis According to Immunophenotypic Subtypes Including the Early T-Cell Precursor Subtype of T-Lymphoblastic Lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 Study.
Clinical Features and Prognosis According to Immunophenotypic Subtypes Including the Early T-Cell Precursor Subtype of T-Lymphoblastic Lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 Study.
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日本小儿白血病/淋巴瘤研究组 ALB-NHL03 研究中根据免疫表型亚型（包括 T 淋巴细胞淋巴瘤的早期 T 细胞前体亚型）的临床特征和预后。
DOI：
10.1097/mph.0000000000000850
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发表时间：
2018
期刊：
影响因子：
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通讯作者：
Tsurusawa M
中科院分区：
文献类型：
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作者：
Fukano R;Sunami S;Sekimizu M;Takimoto T;Mori T;Mitsui T;Mori T;Saito AM;Watanabe T;Ohshima K;Fujimoto J;Nakazawa A;Kiyokawa N;Kobayashi R;Horibe K;Tsurusawa M
我们回顾了日本儿童白血病/淋巴瘤研究小组ALB-NHL03研究中儿童T细胞淋巴母细胞淋巴瘤的免疫表型亚型。在104名患者中，40名患者各有足够的数据来评估免疫表型和早期T细胞前体(ETP)亚型。前T细胞1例，前T细胞9例，中间T细胞21例，成熟T细胞9例。PRO-T/Pre-T、中间T细胞和成熟T细胞的3年无事件生存率分别为80.0±12.6%、71.4±9.9%和88.9±10.5%(P=0.546)。ETP亚型8例，非ETP亚型32例，3年EFS率分别为75.0±15.3%和71.9±8.0%(P=0.828)，提示免疫表型不能预测EFS。
We reviewed the immunophenotypic subtypes of pediatric T-cell lymphoblastic lymphoma in the Japanese Pediatric Leukemia/Lymphoma Study Group ALB-NHL03 study. Of the 104 patients, 40 patients each had sufficient data to evaluate the immunophenotypes and early T-cell precursor (ETP) subtype. Pro-T, pre-T, intermediate T, and mature T cells were observed in 1, 9, 21, and 9 cases, respectively. The 3-year event-free survival (EFS) rates of those with pro-T/pre-T, intermediate T, and mature T cells were 80.0±12.6%, 71.4±9.9%, and 88.9±10.5%, respectively (P= 0.546). There were 8 and 32 cases of ETP and non-ETP subtypes, with 3-year EFS rates of 75.0±15.3% and 71.9±8.0%, respectively (P= 0.828), indicating that the immunophenotypic subtype was not predictive of EFS in this study.