Carotid Intraplaque Hemorrhage Imaging with Quantitative Vessel Wall T1 Mapping: Technical Development and Initial Experience.
Carotid Intraplaque Hemorrhage Imaging with Quantitative Vessel Wall T1 Mapping: Technical Development and Initial Experience.
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颈动脉斑块内出血成像与定量血管壁 T1 映射：技术开发和初步经验
DOI：
10.1148/radiol.2017170526
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发表时间：
2018-04
期刊：
影响因子：
19.7
通讯作者：
Chen H
中科院分区：
文献类型：
--
作者：
Qi H;Sun J;Qiao H;Chen S;Zhou Z;Pan X;Wang Y;Zhao X;Li R;Yuan C;Chen H
目的建立一种三维高空间分辨率时间效率序列，用于血管壁T1定量标测。材料与方法通过引入三维黄金角径向k空间采样（GOAL-SNAP），扩展了先前描述的序列，即同步非造影剂血管造影和斑块内出血（SNAP）成像。采用滑动窗口重建方法，对不同反转延迟时间（不同T1对比度）的图像进行体素T1拟合。进行体模研究以测试使用GOAL-SNAP的T1标测相对于二维反转恢复（IR）自旋回波（SE）序列的准确性。在6名健康志愿者中进行了体内研究（平均年龄，27.8岁± 3.0岁[标准差];年龄范围，24-32岁; 5名男性）和5名动脉粥样硬化患者（平均年龄，66.4岁± 5.5岁;范围，60-73岁; 5名男性），比较有和无斑块内出血（IPH）的血管壁切片（每个动脉5个）之间的T1测量值。统计学分析包括Pearson相关系数、Bland-Altman分析和Wilcoxon秩和检验（按受试者排列数据）。结果GOAL-SNAP和IR SE序列的体模T1测量显示出良好的相关性（R2 = 0.99），平均偏差为-25.8毫秒± 43.6，平均百分比误差为4.3% ± 2.5。有IPH和无IPH的切片之间的最小T1显著不同（平均值，371 msec ± 93 vs 944 msec ± 120; P = .01）。正常血管壁和肌肉的T1估计值分别为1195 msec ± 136和1117 msec ± 153。结论GOAL-SNAP序列可实现高空间分辨率（0.8mm各向同性）时间效率（5 min）血管壁T1标测。该序列可以产生更多的定量可重复的生物标志物，用于表征IPH并监测其进展。© RSNA，2017.
Purpose To develop a three-dimensional (3D) high-spatial-resolution time-efficient sequence for use in quantitative vessel wall T1 mapping. Materials and Methods A previously described sequence, simultaneous noncontrast angiography and intraplaque hemorrhage (SNAP) imaging, was extended by introducing 3D golden angle radial k-space sampling (GOAL-SNAP). Sliding window reconstruction was adopted to reconstruct images at different inversion delay times (different T1 contrasts) for voxelwise T1 fitting. Phantom studies were performed to test the accuracy of T1 mapping with GOAL-SNAP against a two-dimensional inversion recovery (IR) spin-echo (SE) sequence. In vivo studies were performed in six healthy volunteers (mean age, 27.8 years ± 3.0 [standard deviation]; age range, 24-32 years; five male) and five patients with atherosclerosis (mean age, 66.4 years ± 5.5; range, 60-73 years; five male) to compare T1 measurements between vessel wall sections (five per artery) with and without intraplaque hemorrhage (IPH). Statistical analyses included Pearson correlation coefficient, Bland-Altman analysis, and Wilcoxon rank-sum test with data permutation by subject. Results Phantom T1 measurements with GOAL-SNAP and IR SE sequences showed excellent correlation (R2 = 0.99), with a mean bias of -25.8 msec ± 43.6 and a mean percentage error of 4.3% ± 2.5. Minimum T1 was significantly different between sections with IPH and those without it (mean, 371 msec ± 93 vs 944 msec ± 120; P = .01). Estimated T1 of normal vessel wall and muscle were 1195 msec ± 136 and 1117 msec ± 153, respectively. Conclusion High-spatial-resolution (0.8 mm isotropic) time-efficient (5 minutes) vessel wall T1 mapping is achieved by using the GOAL-SNAP sequence. This sequence may yield more quantitative reproducible biomarkers with which to characterize IPH and monitor its progression. © RSNA, 2017.
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影响因子：
3.3
作者：
Neumann, Daniel;Breuer, Felix A.;Voelker, Michael;Brandt, Tobias;Griswold, Mark A.;Jakob, Peter M.;Blaimer, Martin
通讯作者：
Blaimer, Martin
影响因子：
39.3
作者：
Michel JB;Virmani R;Arbustini E;Pasterkamp G
通讯作者：
Pasterkamp G
影响因子：
19.7
作者：
Singh, Navneet;Moody, Alan R.;Maggisano, Robert
通讯作者：
Maggisano, Robert
DOI：
10.1186/1532-429x-15-64
发表时间：
2013-07-26
期刊：
Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic Resonance
影响因子：
--
作者：
Raman FS;Kawel-Boehm N;Gai N;Freed M;Han J;Liu CY;Lima JA;Bluemke DA;Liu S
通讯作者：
Liu S
影响因子：
5.3
作者：
Wang X;Sun J;Zhao X;Hippe DS;Hatsukami TS;Liu J;Li R;Canton G;Song Y;Yuan C;CARE-II study investigators
通讯作者：
CARE-II study investigators