Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases
Protein secondary structure analyses from circular dichroism spectroscopy: Methods and reference databases
复制标题
DOI：
10.1002/bip.20853
复制
发表时间：
2008-05-01
期刊：
影响因子：
2.9
通讯作者：
Wallace, B. A.
中科院分区：
文献类型：
--
作者：
Whitmore, Lee;Wallace, B. A.
圆二色（CD）光谱技术多年来一直是分析蛋白质二级结构的一种重要方法。随着同步辐射圆二色（SRCD）技术的出现以及常规CD仪器的改进，能够获取更低波长的数据，并且光谱的信息量也增加了。此外，新的计算和生物信息学方法已经被开发出来，新的参考数据库也已建立，这极大地改进并促进了对CD光谱的分析。本文讨论了蛋白质二级结构分析的最新进展，包括DICHROWEB分析网络服务器的特性。（c）2007威利期刊公司
Circular dichroism (CD) spectroscopy has been a valuable method for the analysis of protein secondary structures for many years. With the advent of synchrotron radiation circular dichroism (SRCD) and improvements in instrumentation for conventional CD, lower wavelength data are obtainable and the information content of the spectra increased. In addition, new computation and bioinformatics methods have been developed and new reference databases have been created, which greatly improve and facilitate the analyses of CD spectra. This article discusses recent developments in the analysis of protein secondary structures, including features of the DICHROWEB analysis webserver. (c) 2007 Wiley Periodicals, Inc.