Modulation of memory processes induced by stimulation of the entorhinal cortex
Modulation of memory processes induced by stimulation of the entorhinal cortex
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刺激内嗅皮层诱导的记忆过程的调节
DOI：
10.1016/0031-9384(77)90171-8
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发表时间：
1977
影响因子：
2.9
通讯作者：
Joe S. Locob
中科院分区：
文献类型：
--
作者：
J. L. Martinez;J. D. McGaugh;Carolyn L. Hanes;Joe S. Locob
本研究探讨了大鼠内嗅皮层的试验后电刺激（3 mA或300 μA;训练后60秒、3小时或6小时）对抑制性或主动性回避反应保持的影响。在抑制性回避任务中，3 mA，而不是300 μA，训练后60秒产生逆行性遗忘。300 μA刺激在训练后3小时产生记忆缺失，而3 mA刺激则无影响。如果在训练后6小时给予，则刺激水平均不影响保留。在主动回避任务中，训练后60秒和3小时给予300 μA，与未手术但未手术的对照大鼠相比，显著促进了获得。3 mA刺激对主动回避任务无影响。在抑制性回避训练后60秒、3小时和6小时给予300 μA刺激时，皮层后放电活动的发生率分别为64%、23%和77%，3 mA刺激时为54%、69%和92%。在观察到遗忘的两种条件下（60秒时为3 mA，3小时时为300 μA），表现出后放电活动的动物比例最低。后放电活动不相关的主动回避性能。
This study investigated the effects of posttrial electrical stimulation of the entorhinal cortex in rats (3 mA or 300 μA; 60 sec, 3 hr or 6 hr after training) on retention of inhibitory or active avoidance responses. In the inhibitory avoidance task 3 mA, but not 300 μA, 60 sec after training produced retrograde amnesia. The 300 μA stimulation produced amnesia when given 3 hr after training, but 3 mA was without effect. Neither level of stimulation affected retention if given 6 hr after training. In the active avoidance task 300 μA given 60 sec and 3 hr after training significantly facilitated acquisition in comparison with unoperated, but not operated control rats. The 3 mA stimulation had no effect in the active avoidance task. Cortical afterdischarge activity occurred 64%, 23%, and 77% of the time when the 300 μA stimulation was given 60 sec, 3 hr, or 6 hr after inhibitory avoidance training, and 54%, 69%, and 92% for 3 mA. In the two conditions where amnesia was observed (3 mA at 60 sec and 300 μA at 3 hr) the lowest proportion of animals exhibited afterdischarge activity. Afterdischarge activity was not related to active avoidance performance.