Maternal-fetal transfer of a state of idiotypic suppression.
Maternal-fetal transfer of a state of idiotypic suppression.
复制标题
独特型抑制状态的母胎转移。
DOI：
10.1111/j.1749-6632.1983.tb18053.x
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发表时间：
1983
影响因子：
5.2
通讯作者：
Kresina,TF
中科院分区：
文献类型：
--
作者：
Nisonoff,A;Gurish,MF;Kresina,TF
在本文中，我们将审查最近的数据表明，一个独特的抑制状态从一个雌性小鼠转移到其后代时，母亲给予T细胞或血清从同基因供体已被抑制的独特型和超免疫。当直接接种到新生小鼠中时，血清因子（或因子）也可诱导独特型抑制。最初诱导抑制的血清组分似乎不是免疫球蛋白;然而，从母亲转移到胎儿的抑制物质的性质尚不清楚。在介绍这些数据之前，我们将简要回顾一下我们早期关于抑制独特型的一些工作。
In this paper we will review recent data indicating that a state of idiotypic suppression is transferred from a female mouse to its offspring when the mother is given T cells or serum from a syngeneic donor that has been suppressed with respect to that idiotype and hyperimmunized. The serum factor (or factors) can also induce idiotype suppression when inoculated directly into a neonatal mouse. The component of serum that initially induces suppression appears not to be an immunoglobulin; however, the nature of the suppressive substance that is transferred from mother to fetus is not yet known. Before presenting these data some of our earlier work on suppression of idiotype will be reviewed briefly.