Specific killing effect of 10B1-para-boronophenylalanine in thermal neutron capture therapy of malignant melanoma: in vitro radiobiological evaluation.
Specific killing effect of 10B1-para-boronophenylalanine in thermal neutron capture therapy of malignant melanoma: in vitro radiobiological evaluation.
复制标题
10B1-对硼苯丙氨酸在恶性黑色素瘤热中子捕获治疗中的特异性杀伤作用：体外放射生物学评价。
DOI：
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发表时间：
1982
影响因子：
6.5
通讯作者：
Yutaka Mishima
中科院分区：
文献类型：
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作者：
M. Ichihashi;T. Nakanishi;Yutaka Mishima
已发现10 B-dopa类似物10 B1-对硼苯丙氨酸（10 B1-BPA）具有显著的黑色素瘤杀伤作用，如Do值0.9-1.2 × 10（12）n/cm 2所示。中子本身的Do值为2.8 × 10 ~（12）n/cm ~ 2。高LET照射引入放射治疗后，其在靶细胞中的高能量沉积是目前需要解决的主要问题之一。这可以通过我们的热中子捕获治疗在细胞尺寸的顺序，当我们有高度肿瘤寻求10 B-化合物可用。我们目前的证据似乎表明，我们的新10 B1-BPA可以高度浓缩10 B进入黑色素瘤细胞，高达11倍的水平，在体外系统中的培养基。
A 10B-dopa analogue, 10B1-para-boronophenylalanine (10B1-BPA) has been found to have a marked melanoma killing effect as expressed by the Do value, 0.9-1.2 X 10(12) n/cm2. The Do value of the neutron alone is 2.8 X 10(12) n/cm2. After the introduction of high LET irradiation into radiotherapy, its higher energy deposition in the target cancer cells is one of the major problems currently to be solved. This can be achieved by our thermal neutron capture therapy in the order of cellular dimensions when we have highly tumor-seeking 10B-compounds available. Our present evidence seems to indicate that our new 10B1-BPA can highly concentrate 10B into melanoma cells, to as much as 11 times the level of the medium in the in vitro system.