Effect of co-infection with a small intestine-restricted helminth pathogen on oral prion disease pathogenesis in mice.
Effect of co-infection with a small intestine-restricted helminth pathogen on oral prion disease pathogenesis in mice.
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与小肠限制性蠕虫病原体共同感染对小鼠口腔朊病毒病发病机制的影响。
DOI：
10.1038/s41598-019-42900-9
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发表时间：
2019
影响因子：
4.6
通讯作者：
Sánchez-Quintero A
中科院分区：
文献类型：
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作者：
Sánchez-Quintero A
一些口服获得的Pron菌株在小肠Peyer‘s补片内的基质来源的滤泡树突状细胞(FDC)上的早期复制对于建立宿主感染和疾病有效地传播到大脑是至关重要的。影响Pryer‘s斑块早期蛋白积聚的因素可以直接影响疾病的发病机制。宿主对胃肠道蠕虫感染的免疫反应可以改变与某些致病细菌和病毒混合感染的敏感性。在这里，我们使用自然的小鼠小肠限制性蠕虫致病原多螺旋体螺旋体来检验蠕虫合并感染引起的小肠内特异性病理改变会影响口腔普恩病毒病发病机制的假说。小鼠在感染病毒后第8天与病毒混合感染。多发性脑回感染：早期在Peyer‘s斑块内的蛋白积聚减少，存活时间显着延长。绵羊、鹿和牛等对Prion易感的天然宿主经常接触到胃肠道蠕虫寄生虫。我们的数据表明，与小肠限制性蠕虫病原体的混合感染可能是影响口腔Pron病发病机制的重要因素。
The early replication of some orally-acquired prion strains upon stromal-derived follicular dendritic cells (FDC) within the small intestinal Peyer’s patches is essential to establish host infection, and for the disease to efficiently spread to the brain. Factors that influence the early accumulation of prions in Peyer’s patches can directly influence disease pathogenesis. The host’s immune response to a gastrointestinal helminth infection can alter susceptibility to co-infection with certain pathogenic bacteria and viruses. Here we used the natural mouse small intestine-restricted helminth pathogenHeligmosomoides polygyrusto test the hypothesis that pathology specifically within the small intestine caused by a helminth co-infection would influence oral prion disease pathogenesis. When mice were co-infected with prions on d 8 afterH. polygyrusinfection the early accumulation of prions within Peyer’s patches was reduced and survival times significantly extended. Natural prion susceptible hosts such as sheep, deer and cattle are regularly exposed to gastrointestinal helminth parasites. Our data suggest that co-infections with small intestine-restricted helminth pathogens may be important factors that influence oral prion disease pathogenesis.