Cystatin C-based equations in renal transplantation: Moving toward a better glomerular filtration rate prediction?
Cystatin C-based equations in renal transplantation: Moving toward a better glomerular filtration rate prediction?
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DOI：
10.1097/tp.0b013e3181744225
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发表时间：
2008-06-27
期刊：
影响因子：
6.2
通讯作者：
Berthoux, Francois
中科院分区：
文献类型：
--
作者：
Maillard, Nicolas;Mariat, Christophe;Berthoux, Francois
基于肌酐的肾小球滤过率（GFR）估计在肾移植受者中表现不佳。胱抑素C在评估肾移植功能方面可能是比血清肌酐更好的选择。我们比较了几种基于胱抑素c的方程与改良饮食肾病（MDRD）方程在120名成人肾移植受者中，他们的GFR是通过金标准菊粉清除率来测量的。菊粉测定的平均GFR为52.6 mL/min/1.73 m(2)（范围13-119）。Hoek、Rule、Le Bricon和Filler基于胱抑素c的公式表现出明显更好的性能（82%、81%、78%和71%的准确率为30%），而MDRD方程(58%，Mac Nemar检验，P
Creatinine-based glomerular filtration rate (GFR) estimators perform poorly in renal transplant recipients. Cystatin C might be a better alternative to serum creatinine in assessing renal graft function. We compared several cystatin C-based equations with the modification diet renal disease (MDRD) equation in 120 adult renal transplant recipients for whom the GFR was measured by the gold standard inulin clearance. Mean inulin-measured GFR was 52.6 mL/min/1.73 m(2) (range, 13-119). The Hoek, Rule, Le Bricon, and Filler cystatin C-based formulas showed significantly better performances (accuracy 30% of 82%, 81%, 78%, and 71%), than the MDRD equation (58%, Mac Nemar test, P