NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
NRG1 regulates redox homeostasis via NRF2 in papillary thyroid cancer.
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NRG1 通过 NRF2 调节甲状腺乳头状癌中的氧化还原稳态
DOI：
10.3892/ijo.2018.4426
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发表时间：
2018-08
影响因子：
5.2
通讯作者：
Shi RL
中科院分区：
文献类型：
--
作者：
Zhang TT;Qu N;Sun GH;Zhang L;Wang YJ;Mu XM;Wei WJ;Wang YL;Wang Y;Ji QH;Zhu YX;Shi RL
Thyroid cancer is a common endocrine cancer, of which papillary thyroid cancer (PTC) is the most common type. Neuregulin 1 (NRG1), a glycoprotein mediating cell-cell signaling, plays vital roles in cellular activities; however, its role in PTC progression remains poorly understood. In this study, we performed immunohistochemistry in 196 samples from patients and found that NRG1, a potential prognostic marker is highly expressed in PTC compared with adjacent normal tissues. Cell Counting kit-8 (CCK-8) and clone formation assays indicated that NRG1 is essential for PTC cell viability and proliferation, probably by regulating redox homeostasis, which was implied by ROS generation analysis and intracellular GSH activity assay. Western blot analysis and RT-qPCR revealed that NRG1 regulates ERK pathway and the pivotal regulator of cellular redox status, nuclear factor E2-related factor 2 (NRF2), which maintains moderate reactive oxygen species (ROS) levels through a set of antioxidant response element (ARE)-containing genes. The immuno-histochemical scoring of 196 PTC samples and the analysis of the data of 490 patients from The Cancer Genome Atlas (TCGA) reveled a positive association between the expression of NRG1 and NRF2. Since the presence of NRG1 regulates redox homeostasis through NRF2, protecting PTC cells from the accumulation of ROS and ROS-induced cell death, NRG1 may thus prove to be a potential therapeutic target in the treatment of thyroid cancer.
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影响因子：
11.2
作者：
Dai B;Yoo SY;Bartholomeusz G;Graham RA;Majidi M;Yan S;Meng J;Ji L;Coombes K;Minna JD;Fang B;Roth JA
通讯作者：
Roth JA
影响因子：
4.4
作者：
Stefansson, H;Steinthorsdottir, V;Stefansson, K
通讯作者：
Stefansson, K
影响因子：
10.5
作者：
Jaramillo MC;Zhang DD
通讯作者：
Zhang DD
p53和苹果酶的相互调节调节新陈代谢和衰老。
影响因子：
64.8
作者：
通讯作者：
--
影响因子：
6.6
作者：
Haugen, Bryan R.;Alexander, Erik K.;Wartofsky, Leonard
通讯作者：
Wartofsky, Leonard