Melanoma in children and teenagers: An analysis of patients from the National Cancer Data Base
Melanoma in children and teenagers: An analysis of patients from the National Cancer Data Base
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DOI：
10.1200/jco.2006.08.8310
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发表时间：
2007-04-10
影响因子：
45.3
通讯作者：
Balch, Charles M.
中科院分区：
文献类型：
--
作者：
Lange, Julie R.;Palis, Bryan E.;Balch, Charles M.
本研究利用美国医院肿瘤学数据库对儿童和青少年黑色素瘤患者的人口学特征、表现形式和预后进行了研究。研究对象和方法对1985年至2003年国家癌症数据库中1-19岁的患者以及20-24岁的对照组患者的人口学特征、表现和生存情况进行了分析。计算双侧线性和皮尔逊卡氏(2)检验来检查相关性。比例比较使用双侧z检验。使用Kaplan-Meier方法和对数等级检验评估五年的总体观察生存率。结果在3158例1~19岁患者中，皮肤黑色素瘤占96.3%，眼部黑色素瘤占3.0%，原发肿瘤不明占0.7%。皮肤黑色素瘤在1至19岁的患者中更常见于女孩(55.5%)和10岁以上的患者(90.5%)。皮肤黑色素瘤的人口学特征和表现与年龄有关；年龄较小的儿童明显更有可能是非白人和男性，更有可能出现头颈部原发肿瘤和区域或远处转移(直线卡方(2)，P
PurposeThis study examines the demographics, presentation, and outcomes of children and teenagers with melanoma using a US hospital-based oncology database.Patients and MethodsData from the National Cancer Data Base from 1985 through 2003 were examined for demographics, presentation, and survival of patients aged 1 to 19 years, as well as a comparison group of patients aged 20 to 24 years. Two-sided linear and Pearson chi(2) tests were calculated to examine associations. Proportions were compared using two-sided z tests. Five-year overall observed survival was evaluated using the Kaplan-Meier method and the log-rank test. Cox proportional hazards regression was used to estimate risk of mortality.ResultsOf 3,158 patients aged 1 to 19 years, 96.3% had cutaneous melanoma, 3.0% had ocular melanoma, and 0.7% had an unknown primary tumor. Cutaneous melanoma in patients aged 1 to 19 years was more common in girls (55.5%) and patients older than 10 years (90.5%). The demographics and presentation of cutaneous melanoma were age related; younger children were significantly more likely to be nonwhite and male and more likely to present with a head and neck primary tumors and with regional or distant metastases ( linear chi(2), P