Midlife dietary intake of antioxidants and risk of late-life incident dementia - The Honolulu-Asia Aging Study
Midlife dietary intake of antioxidants and risk of late-life incident dementia - The Honolulu-Asia Aging Study
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DOI：
10.1093/aje/kwh124
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发表时间：
2004-05-15
影响因子：
5
通讯作者：
Launer, LJ
中科院分区：
文献类型：
--
作者：
Laurin, D;Masaki, KH;Launer, LJ
抗氧化剂一直被认为可以预防阿尔茨海默氏症，但在晚年进行的研究一直不一致。在中年测量的风险因素可能更好地预测晚年的痴呆症，因为它们受疾病过程的影响较小。作者调查了中年饮食中抗氧化剂摄入量与老年痴呆及其亚型的关系。数据来自檀香山-亚洲老龄化研究，这是一项基于社区的前瞻性研究，研究对象是1965-1968年间年龄在45岁至68岁的日裔美国男性，当时进行了24小时饮食召回。这项分析包括2459名饮食数据完整的男性，他们在1991-1993年的第一次评估中没有痴呆症，并在1991-1999年间接受了两次痴呆症检查。样本包括235例痴呆事件(102例阿尔茨海默病，38例阿尔茨海默病伴发脑血管疾病，44例血管性痴呆)。以年龄为时间尺度，在调整了社会人口学和生活方式因素、心血管危险因素、其他饮食成分和载脂蛋白E e4之后，使用COX比例风险模型计算了按摄入量的四分位数计算的相对风险。摄入β-胡萝卜素、类黄酮类、维生素E和C与痴呆症或其亚型的风险无关。这项分析表明，中年饮食中摄入抗氧化剂并不会改变老年痴呆或其最常见的亚型的风险。
Antioxidants have been hypothesized to protect against Alzheimer's disease, but studies conducted in late life have been inconsistent. Risk factors measured in midlife may better predict dementia in late life because they are less affected by the disease process. The authors examined the association of midlife dietary intake of antioxidants to late-life dementia and its subtypes. Data were obtained from the Honolulu-Asia Aging Study, a prospective community-based study of Japanese-American men who were aged 45-68 years in 1965-1968, when a 24-hour dietary recall was administered. The analysis included 2,459 men with complete dietary data who were dementia-free at the first assessment in 1991-1993 and were examined up to two times for dementia between 1991 and 1999. The sample included 235 incident cases of dementia (102 cases of Alzheimer's disease, 38 cases of Alzheimer's disease with contributing cerebrovascular disease, and 44 cases of vascular dementia). Relative risks by quartile of intake were calculated using Cox proportional hazards models with age as the time scale, after adjustment for sociodemographic and lifestyle factors, cardiovascular risk factors, other dietary constituents, and apolipoprotein E e4. Intakes of beta-carotene, flavonoids, and vitamins E and C were not associated with the risk of dementia or its subtypes. This analysis suggests that midlife dietary intake of antioxidants does not modify the risk of late-life dementia or its most prevalent subtypes.