Epigenetic regulation of immune function in asthma.
Epigenetic regulation of immune function in asthma.
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DOI：
10.1016/j.jaci.2022.06.002
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发表时间：
2022-08
影响因子：
14.2
通讯作者：
Schwartz, David A.
中科院分区：
文献类型：
--
作者：
Sharma, Sunita;Yang, Ivana, V;Schwartz, David A.
哮喘是一种常见的复杂呼吸系统疾病，其特征是慢性气道炎症以及由遗传和环境因素导致的部分可逆性气流受限。由于表观遗传标记影响基因表达，并且可被环境暴露和遗传变异所改变，它们越来越被认为与哮喘的发病机制相关，并且可能是环境暴露与哮喘易感性之间的关键联系。与DNA序列的改变不同，表观遗传特征是动态且可逆的，这不仅为治疗靶点创造了机会，还可作为生物标志物来追踪疾病进程以及识别像哮喘这类异质性疾病的分子亚型。在这篇综述中，我们将探讨哮喘与三种关键的可改变基因表达的表观遗传过程之间的关系：DNA甲基化、组蛋白尾部修饰和非编码RNA。除了对现有的专注于哮喘免疫调节的表观遗传研究进行全面评估外，我们还将讨论过敏性气道疾病表观遗传研究的未来方向。
Asthma is a common complex respiratory disease characterized by chronic airway inflammation and partially reversible airflow obstruction resulting from genetic and environmental determinants. Since epigenetic marks influence gene expression and can be modified by both environmental exposures and genetic variation they are increasingly recognized as relevant to the pathogenesis of asthma and may be a key link between environmental exposures and asthma susceptibility. Unlike changes to DNA sequence, epigenetic signatures are dynamic and reversible, creating an opportunity for not only therapeutic targets but may serve as biomarkers to follow disease course and identify molecular subtypes in heterogeneous diseases such as asthma. In this review, we will examine the relationship between asthma and three key epigenetic processes that modify gene expression: DNA methylation, modification of histone tails, and non-coding RNAs. In addition to presenting a comprehensive assessment of the existing epigenetic studies focusing on immune regulation in asthma, we will also discuss future directions for epigenetic investigation in allergic airway disease.
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影响因子：
5.7
作者：
Arathimos R;Suderman M;Sharp GC;Burrows K;Granell R;Tilling K;Gaunt TR;Henderson J;Ring S;Richmond RC;Relton CL
通讯作者：
Relton CL
DOI：
10.4049/jimmunol.0903610
发表时间：
2010-09-15
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Grausenburger R;Bilic I;Boucheron N;Zupkovitz G;El-Housseiny L;Tschismarov R;Zhang Y;Rembold M;Gaisberger M;Hartl A;Epstein MM;Matthias P;Seiser C;Ellmeier W
通讯作者：
Ellmeier W
影响因子：
3.7
作者：
Davis JS;Sun M;Kho AT;Moore KG;Sylvia JM;Weiss ST;Lu Q;Tantisira KG
通讯作者：
Tantisira KG
影响因子：
9.8
作者：
Hannon E;Gorrie-Stone TJ;Smart MC;Burrage J;Hughes A;Bao Y;Kumari M;Schalkwyk LC;Mill J
通讯作者：
Mill J
影响因子：
3.1
作者：
Dong Z;Ma Y;Zhou H;Shi L;Ye G;Yang L;Liu P;Zhou L
通讯作者：
Zhou L