Antinociceptive activities of 70% methanol extract of evodiae fructus (fruit of Evodia rutaecarpa var. bodinieri) and its alkaloidal components
Antinociceptive activities of 70% methanol extract of evodiae fructus (fruit of Evodia rutaecarpa var. bodinieri) and its alkaloidal components
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DOI：
10.1248/bpb.20.243
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发表时间：
1997-03-01
影响因子：
2
通讯作者：
Kubo, M
中科院分区：
文献类型：
--
作者：
Matsuda, H;Wu, JX;Kubo, M
以吴茱萸干果为原料，研究了吴茱萸70%甲醇提取物(EA-EXT)的药效。研究了灯盏花(Rutaceae)对伤害反应的影响。口服50或200 mg/kg的EA-EXT对小鼠扭体反应的抑制作用与醋酸相同。其主要生物碱成分吴茱萸碱和吴茱萸次碱也具有抗伤害性作用。在福尔马林实验的早期阶段，电针-EXT可显著降低单位时间内小鼠的舔食行为频率，而不影响早期阶段的舔食行为频率。在Randall-Selitto实验中，EA-ext还提高了炎症爪子的伤害性阈值，而不增加非炎症爪子的伤害性阈值。EA-EXT虽能抑制醋酸引起的血管通透性升高和角叉菜胶引起的足肿胀，但对热板法的伤害性反应和小鼠的运动活动无明显影响。以上结果提示，电针具有抗伤害性作用，其作用机制可能与抗炎作用有关，抗伤害性成分仅部分归因于上述生物碱类成分。
The effects of 70% methanol extract (EA-ext) from Evodiae Fructus (EA) consisting of dried fruits of Evodia rutaecarpa var. bodinieri (Rutaceae) on nociceptive responses were investigated. Oral administration of 50 or 200 mg/kg EA-ext had the same antinociceptive effect on writhing responses as induced by acetic acid. Its major alkaloidal constituents, evodiamine and rutaecarpine also had the antinociceptive effect. EA-ext significantly decreased the frequency of licking behavior within a unit of time at the late phase without affecting that of the early phase in the formalin test. EA-ext also increased nociceptive threshold of the inflamed paw without increasing that in the non-inflamed paw in the Randall-Selitto test. Although EA-ext inhibited the rise of vascular permeability induced by acetic acid and the increase of paw edema induced by carrageenin, it was ineffective on nociceptive response in the hot plate test and on locomotor activity. These results suggest that EA possesses antinociceptive effects and its mode of action may be mediated by anti-inflammatory action, and that the antinociceptive constituents are only partially attributable to alkaloidal components mentioned above.