Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds.
Evaluation of Antithrombogenicity and Hydrophilicity on Zein-SWCNT Electrospun Fibrous Nanocomposite Scaffolds.
复制标题
DOI：
10.1155/2012/345029
复制
发表时间：
2012
影响因子：
3.1
通讯作者：
Sakthikumar D
中科院分区：
文献类型：
--
作者：
Dhandayuthapani B;Varghese SH;Aswathy RG;Yoshida Y;Maekawa T;Sakthikumar D
血液相容性表面的设计是必要的，以尽量减少血小板表面的相互作用，并增加外来表面的抗血栓性时，他们被用作生物材料，特别是人工血液假体。本研究采用静电纺丝法制备了单壁碳纳米管和玉米醇溶蛋白纤维纳米复合支架，并对其抗凝血性和亲水性进行了评价。采用静电纺丝法成功制备了不同单壁碳纳米管含量（0.2wt%~ 1wt%）的玉米醇溶蛋白复合纳米纤维，纤维表面均匀光滑，未出现珠状缺陷。所得纤维直径在100-300 nm范围内，没有任何珠。通过多种方法，包括扫描电子显微镜，透射电子显微镜，热重分析，和拉伸力学测试的复合纳米纤维与单壁碳纳米管和没有。随着单壁碳纳米管的加入，复合支架的吸水性和保水性降低，而热稳定性增加。研究了纳米复合材料（Zein-SWCNTs）的溶血性能和血小板粘附能力。这些观察结果表明，新型玉米醇溶蛋白-单壁碳纳米管复合支架可能具有很大的希望，作为有用的抗血栓材料和有前途的生物材料的组织工程应用。
Design of blood compatible surfaces is required to minimize platelet surface interactions and increase the thromboresistance of foreign surfaces when they are used as biomaterials especially for artificial blood prostheses. In this study, single wall carbon nanotubes (SWCNTs) and Zein fibrous nanocomposite scaffolds were fabricated by electrospinning and evaluated its antithrombogenicity and hydrophilicity. The uniform and highly smooth nanofibers of Zein composited with different SWCNTs content (ranging from 0.2 wt% to 1 wt%) were successfully prepared by electrospinning method without the occurrence of bead defects. The resulting fiber diameters were in the range of 100–300 nm without any beads. Composite nanofibers with and without SWCNT were characterized through a variety of methods including scanning electron microscopy, transmission electron microscopy, thermogravimetric analysis, and tensile mechanical testing. The water uptake and retention ability of composite scaffolds decreased whereas thermal stability increased with an addition of SWCNTs. Hemolytic property and platelet adhesion ability of the nanocomposite (Zein-SWCNTs) were explored. These observations suggest that the novel Zein-SWCNTs composite scaffolds may possibly hold great promises as useful antithrombotic material and promising biomaterials for tissue engineering application.