Hindered biaryls by C-H coupling: bisoxazoline-Pd catalysis leading to enantioselective C-H coupling
Hindered biaryls by C-H coupling: bisoxazoline-Pd catalysis leading to enantioselective C-H coupling
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DOI：
10.1039/c2sc20277h
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发表时间：
2012-01-01
期刊：
影响因子：
8.4
通讯作者：
Itami, Kenichiro
中科院分区：
文献类型：
--
作者：
Yamaguchi, Kazuya;Yamaguchi, Junichiro;Itami, Kenichiro
发现了一种新的钯催化的位阻杂芳烃与芳基硼酸的C-H/C-B偶联反应。新建立的Pd（OAc）（2）/bisoxazoline/克里思体系不仅能够合成空间位阻的杂联芳基化合物，而且还提供了通过C-H官能化实现对映选择性联芳基偶联的机会。
A new Pd-catalyzed C-H/C-B coupling of sterically hindered heteroarenes and arylboronic acids has been identified. The newly established Pd(OAc)(2)/bisoxazoline/TEMPO system not only enables the synthesis of sterically hindered heterobiaryls but also offers an opportunity for enantioselective biaryl coupling through C-H functionalization.