Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis
Association between estrogen receptor gene polymorphisms and curve severity of idiopathic scoliosis
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DOI：
10.1097/00007632-200211010-00009
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发表时间：
2002-11-01
期刊：
影响因子：
3
通讯作者：
Moriya, H
中科院分区：
文献类型：
--
作者：
Inoue, M;Minami, S;Moriya, H
研究设计.特发性脊柱侧凸女孩雌激素受体基因分析确定雌激素受体基因多态性是否与青少年特发性脊柱侧凸的弯曲严重程度相关。研究表明，特发性脊柱侧凸是一种家族性疾病，脊柱侧弯的进展与遗传因素有关，如骨骼发育和性发育。共有304名患有特发性脊柱侧凸的女孩被随访至发育成熟。用聚合酶链反应从淋巴细胞DNA中扩增出雌激素受体基因，该基因含有Pvu Ⅱ和Xba Ⅰ多态性位点。基因型为XX和Xx的患者的平均最大Cobb测量值大于基因型为XX的患者（P=0.002）。曲线进展的风险，定义为从初始评估开始进展> 5度，Xx基因型比xx基因型高（P=0.03）。XX和Xx基因型患者手术治疗的风险显著高于xx基因型患者（21.4%，24.7%vs.7.6%，P
Study Design. Analysis of the estrogen receptor gene of girls with idiopathic scoliosis.Objectives. To determine whether estrogen receptor gene polymorphisms correlate with curve severity of adolescent idiopathic scoliosis.Summary of Background Data. Studies suggest that idiopathic scoliosis is a familial condition and that curve progression is related to genetically determined factors, such as skeletal and sexual growth.Methods. A total of 304 girls with idiopathic scoliosis were followed until growth maturation. Height arm span menarcheal age, and age at growth maturation were recorded, and curve severity was measured using Cobb's method, The estrogen receptor gene, which contains polymorphic PvuII and XbaI sites, was amplified form lymphocyte deoxyribonucleic acid by polymerase chain reaction.Results. The mean maximum Cobb measurements for patients with genotyped XX and Xx were greater than for those with genotype xx (P=0.002). The risk of curve progression, defined as progression of >5degrees form initial evaluation, was higher with genotype Xx than with xx (P=0.03). Patients with genotypes XX and Xx had a significantly higher risk for operative treatment than those with genotype xx (21.4%, 24.7% vs. 7.6%, P