Vinylogous Mannich-type reaction catalyzed by an iodine-substituted chiral phosphoric acid
Vinylogous Mannich-type reaction catalyzed by an iodine-substituted chiral phosphoric acid
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DOI：
10.1002/adsc.200700521
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发表时间：
2008-02-01
影响因子：
5.4
通讯作者：
Fuchibe, Kohei
中科院分区：
文献类型：
--
作者：
Akiyama, Takahiko;Honma, Yasuhiro;Fuchibe, Kohei
2-三甲基硅氧基呋喃在联萘基的 6,6'-位上带有碘的新型手性磷酸的作用下与醛亚胺进行插烯曼尼希型反应，作为手性布朗斯台德酸，得到具有高非对映和对映选择性的氨基官能团的 γ-丁烯内酯衍生物。
2-Trimethylsiloxyfuran underwent a vinylogous Mannich-type reaction with aldimines under the action of a new chiral phosphoric acid, bearing iodine on the 6,6'-positions of the binaphthyl group, as a chiral Bronsted acid to give gamma-butenolide derivatives bearing an amino functionality with high diastereo- and enantioselectivity.