Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1.
Adverse birth outcomes associated with maternal smoking and polymorphisms in the N-Nitrosamine-metabolizing enzyme genes NQO1 and CYP2E1.
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DOI：
10.1093/aje/kwm360
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发表时间：
2007-12
影响因子：
5
通讯作者：
S. Sasaki;F. Sata;S. Katoh;Y. Saijo;S. Nakajima;N. Washino;Kanae Konishi;S. Ban;M. Ishizuka;R. Kishi
中科院分区：
文献类型：
--
作者：
S. Sasaki;F. Sata;S. Katoh;Y. Saijo;S. Nakajima;N. Washino;Kanae Konishi;S. Ban;M. Ishizuka;R. Kishi
母亲在怀孕期间吸烟会导致妊娠并发症和胎儿和新生儿的尺寸减小。在吸烟的女性中，对烟草烟雾的遗传易感性也是不良妊娠结局的可能致病因素。对2002年至2005年在日本札幌分娩活产单胎的460名孕妇进行了一项前瞻性队列研究。采用多元线性回归模型估计母亲吸烟和编码N-亚硝胺代谢酶NAD（P）H：醌氧化还原酶1（NQO 1）和细胞色素P-450 2 E1（CYP 2 E1）的两个基因多态性与出生大小的关联。在携带NQO 1纯合野生型等位基因的吸烟者所生的婴儿中，出生体重、出生身长和出生头围显著降低（每个因素p < 0.01）。对于纯合子野生型CYP 2 E1等位基因，吸烟者的出生体重估计低195 g（标准误55; p < 0.001）。这些基因型对从未吸烟或在怀孕前三个月戒烟的妇女没有不利影响。母亲吸烟对婴儿出生大小的不利影响可能会被修改的N-亚硝胺代谢酶在日本受试者的母亲遗传多态性。这些结果可能有助于指导怀孕期间的戒烟干预，特别是在易感妇女中。
Maternal smoking during pregnancy can result in both pregnancy complications and reduced size of the fetus and neonate. Among women who smoke, genetic susceptibility to tobacco smoke also is a likely causative factor in adverse pregnancy outcomes. A prospective cohort study was conducted among 460 pregnant women who delivered live singletons in Sapporo, Japan, from 2002 to 2005. Multiple linear regression models were used to estimate associations of maternal smoking and polymorphisms in two genes encoding N-nitrosamine-metabolizing enzymes-NAD(P)H: quinone oxidoreductase 1 (NQO1) and cytochrome P-450 2E1 (CYP2E1)-with birth size. Among infants born to smokers with the NQO1 homozygous wild-type allele, birth weight, birth length, and birth head circumference were significantly reduced (p < 0.01 for each factor). For the homozygous wild-type CYP2E1 allele, birth weight was lower by an estimated 195 g (standard error, 55; p < 0.001) among smokers. These genotypes did not confer adverse effects among women who had never smoked or who quit smoking during the first trimester. The adverse effects of maternal smoking on infant birth size may be modified by maternal genetic polymorphisms in N-nitrosamine-metabolizing enzymes among Japanese subjects. These results may help in directing smoking cessation interventions during pregnancy, especially among susceptible women.