Endothelin: a potent renal and systemic vasoconstrictor peptide.
Endothelin: a potent renal and systemic vasoconstrictor peptide.
复制标题
内皮素：一种有效的肾脏和全身血管收缩肽。
DOI：
10.1152/ajprenal.1989.256.6.f1051
复制
发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Anderson,S
中科院分区：
文献类型：
--
作者：
King,AJ;Brenner,BM;Anderson,S
内皮素是一种内皮细胞衍生的多肽，最近被证明具有强大的血管收缩特性。给麻醉的慕尼黑-Wistar大鼠静脉注射内皮素(5-450pmol)可引起明显的升压效应，升压效应的幅度和持续时间呈剂量依赖性。最大全身和肾脏反应发生在20分钟内，在较高剂量范围内持续90分钟以上。当给药剂量为25pmol或更高时，肾血浆流量的下降比例大于肾小球滤过率，导致滤过分数的增加。在持续静脉输注内皮素(0.63pmol/min)的大鼠的微穿刺法研究中，这种多肽引起的传出动脉阻力比传入小动脉阻力按比例增加，肾小球毛细血管水压显著升高，肾小球毛细血管超滤系数降低。当全身压力升高且肾功能未受到严重损害时，内皮素有适度的利钠作用。这种强大的肾脏和全身血管收缩因子可能在肾小球损伤和各种临床微血管病变的病理生理学中发挥重要作用。
Endothelin is an endothelial cell-derived peptide recently shown to possess potent vasoconstrictor properties. Bolus intravenous injections of endothelin (5-450 pmol) into anesthetized Munich-Wistar rats induced a marked pressor effect, the magnitude and duration of which were dose dependent. Maximal systemic and renal responses occurred within 20 min and persisted for greater than 90 min in the higher dose range. In response to bolus dosages of 25 pmol or greater, renal plasma flow fell proportionately more than glomerular filtration rate, resulting in an increase in filtration fraction. In micropuncture studies of rats given continuous intravenous infusions of endothelin (0.63 pmol/min), the peptide caused a proportionately greater elevation of efferent than afferent arteriolar resistance, with a marked elevation of glomerular capillary hydraulic pressure and a lower glomerular capillary ultrafiltration coefficient. Endothelin was modestly natriuretic when systemic pressure rose and renal function was not severely impaired. This potent renal and systemic vasoconstrictor may play an important role in glomerular injury and in the pathophysiology of a variety of clinical microvasculopathies.