Analysis of crossover designs with nonignorable dropout.
Analysis of crossover designs with nonignorable dropout.
复制标题
具有不可忽略的 dropout 的交叉设计分析。
DOI：
10.1002/sim.8762
复制
发表时间：
2021
影响因子：
2
通讯作者：
Chinchilli,VernonM
中科院分区：
文献类型：
--
作者：
Wang,Xi;Chinchilli,VernonM
This article addresses the analysis of crossover designs with nonignorable dropout. We study nonreplicated crossover designs and replicated designs separately. With a primary objective of comparing the treatment mean effects, we jointly model the longitudinal measures and discrete time to dropout. We propose shared‐parameter models and mixed‐effects selection models. We adapt a linear‐mixed effects model as the conditional model for the longitudinal outcomes. We invoke a discrete‐time hazards model with a complementary log‐log link function for the conditional distribution of time to dropout. We apply maximum likelihood for parameter estimation. We perform simulation studies to investigate the robustness of our proposed approaches under various missing data mechanisms. We then apply the approaches to two examples with a continuous outcome and one example with a binary outcome using existing software. We also implement the controlled multiple imputation methods as a sensitivity analysis of the missing data assumption.
