Patterns and Predictors of Successful Treatment Discontinuation in Retinal Vein Occlusions With Macular Edema in the Real World.
Patterns and Predictors of Successful Treatment Discontinuation in Retinal Vein Occlusions With Macular Edema in the Real World.
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DOI：
10.3928/23258160-20210201-05
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发表时间：
2021-02-01
期刊：
影响因子：
--
通讯作者：
Yiu G
中科院分区：
文献类型：
--
作者：
Lo T;Lent-Schochet D;Luu KY;Kuriyan AE;Weiss MY;Rachitskaya AV;Singh RP;Wai KM;Campbell JP;Gupta K;Nudleman E;Chen KC;Yiu G
确定在现实环境中视网膜静脉阻塞（RVO）和黄斑水肿（ME）患者成功中止治疗的相关因素。在五个学术中心对214只患有RVO和ME的眼睛进行了24个月随访的回顾性研究。回归分析确定了与（1）成功停药至少6个月且无液体复发和（2）24个月时最佳矫正视力（BCVA）相关的因素。40%的分支RVO患眼和35%的中央RVO（CRVO）/半视网膜RVO（HRVO）患眼成功中止治疗，无液体复发，中止治疗的中位时间分别为6和7个月。对于CRVO/HRVO患者，较低的6个月中央子场厚度与24个月内治疗中止的可能性较大相关（P = .001），而对于所有RVO亚型，较好的6个月BCVA与较好的24个月BCVA相关（P < .001）。6个月时的早期解剖学反应与停止治疗的可能性更大相关。
To identify factors associated with successful treatment discontinuation in eyes with retinal vein occlusions (RVOs) and macular edema (ME) in real-world settings. Retrospective study of 214 eyes with RVO and ME with 24-month follow-up at five academic centers. Regression analyses identified factors associated with (1) successful treatment discontinuation for at least 6 months without fluid recurrence and (2) best-corrected visual acuity (BCVA) at 24 months. Forty percent of eyes with branch RVO and 35% with central RVO (CRVO) / hemi-retinal RVO (HRVO) successfully discontinued therapy without fluid recurrence, with median time to discontinuation of 6 and 7 months, respectively. Lower 6-month central subfield thickness was associated with greater likelihood of treatment discontinuation within 24 months for eyes with CRVO/HRVO (P = .001), whereas better 6-month BCVA was associated with better 24-month BCVA for all RVO subtypes (P < .001). Early anatomic response at 6 months is associated with greater likelihood of stopping treatments.
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