Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats
Effects of abused drugs on thresholds and breaking points of intracranial self-stimulation in rats
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DOI：
10.1016/s0924-977x(99)00008-5
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发表时间：
1999-09-01
影响因子：
5.6
通讯作者：
Zvartau, E
中科院分区：
文献类型：
--
作者：
Bespalov, A;Lebedev, A;Zvartau, E
本研究旨在比较各种滥用药物对阈值电流强度和颅内自我刺激断点的影响。吗啡（1-10 mg/kg，s.c.）的作用，d-苯丙胺（0.3-3.2 mg/kg，i. p.），尼古丁（0.1-3.2 mg/kg，皮下注射），乙醇（0.6-2.4 g/kg，p.o.），咖啡因（1-20 mg/kg，i. p.）和苯环利定（0.3- 5.6mg/kg，i. p.）在雄性Wistar大鼠训练的腹侧被盖区的电刺激的背按压。吗啡和d-苯丙胺是仅有的两种既降低阈值电流又增加增强和非增强反应最大比率的药物。尼古丁（1 mg/kg）和乙醇（1.2 g/kg）降低阈值电流，而低（5 mg/kg）和高（20 mg/kg）剂量的咖啡因分别给药后，阈值电流的降低和增加。尼古丁、乙醇和咖啡因对渐进比例程序没有影响。苯环利定的影响没有达到统计学意义的水平，在任何程序，虽然高剂量的苯环利定破坏性能的渐进比例程序。(C)1999 Elsevier Science B. V.保留所有权利。
The present study aimed to compare the effects of various abused drugs on threshold current intensities and the breaking points of intracranial self-stimulation. Effects of morphine (1-10 mg/kg, s.c.), d-amphetamine (0.3-3.2 mg/kg, i.p.), nicotine (0.1-3.2 mg/kg, s.c.), ethanol (0.6-2.4 g/kg, p.o.), caffeine (1-20 mg/kg, i.p.) and phencyclidine (0.3-5.6 mg/kg, i.p.) were studied in male Wistar rats trained to lever-press for electrical stimulation of ventral tegmental area. Morphine and d-amphetamine were the only two drugs that both decreased threshold currents and increased the maximal ratio of reinforced and non-reinforced responses. Nicotine (1 mg/kg) and ethanol (1.2 g/kg) lowered threshold currents while both decreases and increases in threshold current were seen after administration of low (5 mg/kg) and high (20 mg/kg) doses of caffeine, respectively. Nicotine, ethanol and caffeine had no effects in the progressive ratio procedure. Effects of phencyclidine did not reach levels of statistical significance in either procedure although high doses of phencyclidine disrupted performance in the progressive ratio procedure. (C) 1999 Elsevier Science B.V. All rights reserved.