Plasma metabolites in treatment-requiring retinopathy of prematurity: Potential biomarkers identified by metabolomics
Plasma metabolites in treatment-requiring retinopathy of prematurity: Potential biomarkers identified by metabolomics
复制标题
需要治疗的早产儿视网膜病变的血浆代谢物：代谢组学鉴定的潜在生物标志物
DOI：
10.1016/j.exer.2020.108198
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发表时间：
2020-10-01
影响因子：
3.4
通讯作者：
Li, Yun
中科院分区：
文献类型：
--
作者：
Zhou, Yedi;Xu, Yu;Li, Yun
早产儿视网膜病变（ROP）是一种潜在的致盲性疾病，其原因是视网膜血管化和代谢的破坏。本研究旨在确定与对照组相比，需要治疗的ROP（TR-ROP）患者血浆中代谢物的改变。进行非靶向代谢组学分析以揭示TR-ROP患者（n = 38）和年龄匹配的婴儿（n = 23）之间的血浆代谢组学谱。进行了京都基因和基因组百科全书（KEGG）分析，以探索变化代谢物的潜在信号传导途径。在正离子模式下，TR-ROP患者和对照组之间的血浆中总共有29种代谢物发生显著改变，在负离子模式下鉴定出23种改变的代谢物。KEGG分析表明，“蛋白质消化和吸收”和“氨酰-tRNA生物合成”是最丰富的代谢途径的改变。这些结果表明TR-ROP患者血浆中代谢物组学特征发生了变化，其代谢产物可作为TR-ROP患者诊断和预后的潜在生物标志物。此外，代谢组学特征可能为ROP治疗提供新的治疗策略。
Retinopathy of prematurity (ROP) is a potentially blinding condition caused by disruption of retinal vascularization and metabolism. This study aims to identify altered metabolites from plasma in patients with treatment-requiring ROP (TR-ROP) compared with controls. An untargeted metabolomics analysis was performed to reveal the metabolomic profiles of the plasma between TR-ROP patients (n = 38) and age-matched infants (n = 23). The Kyoto Encyclopedia of Genes and Genomes (KEGG) analyses were conducted to explore the potential signaling pathways of the changed metabolites. Under positive ion mode, a total of 29 metabolites were significantly altered in plasma between TR-ROP patients and controls, and 23 altered metabolites were identified under negative ion mode. KEGG analyses indicated that "protein digestion and absorption" and "aminoacyl-tRNA biosynthesis" were the most enriched pathways of the altered metabolites. These results demonstrated that metabolomic profiles changed in plasma of TR-ROP, and the altered metabolites could be served as potential biomarkers for the diagnosis and prognosis of TR-ROP patients. Besides, the metabolomic profiles might provide clues to discover novel therapeutic strategies in ROP treatment.