Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer's disease: Implications for the integrity of semantic memory
Differential decline in word generation from phonemic and semantic categories during the course of Alzheimer's disease: Implications for the integrity of semantic memory
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DOI：
10.1017/s1355617799577126
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发表时间：
1999-11-01
影响因子：
2.6
通讯作者：
Lange, KL
中科院分区：
文献类型：
--
作者：
Salmon, DP;Heindel, WC;Lange, KL
在阿尔茨海默病患者（AD；N = 59）和正常对照（NC：N = 59）中纵向评估从音素（即以“F”、“A”和“S”开头的单词）和语义（即动物、水果和蔬菜）类别生成单词的能力。在 4 次年度评估中，AD 患者在这两项任务上的表现都比 NC 参与者差，并且相对于语义类别任务的对照组，其表现出比音素类别任务更大的损伤。此外，随着时间的推移，AD 患者在这两项任务上的表现都会下降，但语义类别任务的下降速度比音素类别任务的下降速度更快。对年度评估中个人反应的检查表明，在未产生该项目的第一年之后的所有年份中，AD 患者比 NC 参与者在未能生成先前产生的语义类别项目（但不是音素类别项目）方面更加一致。这些结果与 AD 患者的语义记忆的组织和内容随着疾病的进展而逐渐恶化的观点是一致的。
The ability to generate words from phonemic (i.e., words beginning with 'F,' 'A,' and 'S') and semantic (i.e., animals, fruits, and vegetables) categories was assessed longitudinally in patients with Alzheimer's disease (AD; N = 59) and normal controls (NC: N = 59). Patients with AD performed worse than NC participants on both tasks at each of 4 annual evaluations and exhibited greater impairment relative to controls on the semantic-category task than on the phonemic-category task. In addition, the performance of the patients with AD declined over time on both tasks, but the rate of decline was faster on the semantic-category than on the phonemic-category task. Examination of individual responses across the annual evaluations revealed that patients with AD were more consistent than NC participants in failing to generate previously produced semantic-category, but not phonemic-category, items in all years following the Ist year in which the item was not produced. These results are consistent with the notion that patients with AD suffer a gradual deterioration of the organization and content of semantic memory as the disease progresses.