Targeting ARID1A-Deficient Cancers: An Immune-Metabolic Perspective.
Targeting ARID1A-Deficient Cancers: An Immune-Metabolic Perspective.
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表观遗传重塑和代谢重编程是两个众所周知的癌症特征，高度交织在一起。除了赋予癌细胞生长优势的能力外，这些改变在动态塑造肿瘤微环境和抗肿瘤免疫方面发挥着关键作用。最近的研究指出，表观遗传调控和新陈代谢重组之间的相互作用是癌症潜在的靶向阿喀琉斯之踵。在这篇综述中，我们探索了支持富AT相互作用域1A(ARID1A)免疫调节作用的关键代谢机制，ARID1A是人类癌症中最频繁突变的表观遗传调节因子。我们将通过利用ARID1A缺陷引起的免疫代谢脆弱性来刺激抗肿瘤免疫反应，并最终改善患者的预后，来总结针对ARID1A缺陷癌症的最新进展。
Epigenetic remodeling and metabolic reprogramming, two well-known cancer hallmarks, are highly intertwined. In addition to their abilities to confer cancer cell growth advantage, these alterations play a critical role in dynamically shaping the tumor microenvironment and antitumor immunity. Recent studies point toward the interplay between epigenetic regulation and metabolic rewiring as a potentially targetable Achilles’ heel in cancer. In this review, we explore the key metabolic mechanisms that underpin the immunomodulatory role of AT-rich interaction domain 1A (ARID1A), the most frequently mutated epigenetic regulator across human cancers. We will summarize the recent advances in targeting ARID1A-deficient cancers by harnessing immune-metabolic vulnerability elicited by ARID1A deficiency to stimulate antitumor immune response, and ultimately, to improve patient outcome.
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影响因子：
5.6
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通讯作者：
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影响因子：
11.2
作者：
Fukumoto, Takeshi;Fatkhutdinov, Nail;Zhang, Rugang
通讯作者：
Zhang, Rugang
影响因子：
30.8
作者：
Gibson WJ;Hoivik EA;Halle MK;Taylor-Weiner A;Cherniack AD;Berg A;Holst F;Zack TI;Werner HM;Staby KM;Rosenberg M;Stefansson IM;Kusonmano K;Chevalier A;Mauland KK;Trovik J;Krakstad C;Giannakis M;Hodis E;Woie K;Bjorge L;Vintermyr OK;Wala JA;Lawrence MS;Getz G;Carter SL;Beroukhim R;Salvesen HB
通讯作者：
Salvesen HB
影响因子：
82.9
作者：
Lissanu Deribe Y;Sun Y;Terranova C;Khan F;Martinez-Ledesma J;Gay J;Gao G;Mullinax RA;Khor T;Feng N;Lin YH;Wu CC;Reyes C;Peng Q;Robinson F;Inoue A;Kochat V;Liu CG;Asara JM;Moran C;Muller F;Wang J;Fang B;Papadimitrakopoulou V;Wistuba II;Rai K;Marszalek J;Futreal PA
通讯作者：
Futreal PA
DOI：
10.1158/2767-9764.crc-22-0122
发表时间：
2022-08
期刊：
Cancer research communications
影响因子：
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