Irradiation- and cyclophosphamide-induced alterations in Syrian hamster T-cell population activity.
Irradiation- and cyclophosphamide-induced alterations in Syrian hamster T-cell population activity.
复制标题
辐射和环磷酰胺诱导的叙利亚仓鼠 T 细胞群活性变化。
DOI：
10.1002/jlb.39.2.183
复制
发表时间：
1986
影响因子：
5.5
通讯作者：
Tabor,D
中科院分区：
文献类型：
--
作者：
Bagasra,O;Tabor,D
用辐照（IR）或环磷酰胺（DDP）处理仓鼠，以剂量相关方式显著改变其细胞免疫功能的选定方面。可能导致该活性的一种机制似乎是T淋巴细胞亚群的减少，该亚群对B淋巴细胞对抗原的反应性产生抑制性影响。本研究表明，在仓鼠中，免疫易感性受到这些因子（即IR、IR）的大小和方向的影响，因为它们在时间上与抗原免疫和/或攻毒相关。此外，有证据表明T-非依赖性和T-依赖性反应受到这些治疗的影响。因此，环磷酰胺和照射方式可以用来修改仓鼠的细胞免疫反应。
The treatment of hamsters with either irradiation (IR) or cyclophosphamide (CYP) markedly alters select aspects of their cellular immune functions in a dose‐related manner. One mechanism that may be responsible for this activity appears to be the dimunition of a T‐lymphocyte subpopulation that exerts suppressive influence upon the B‐lymphocyte reactivity toward antigens. This study shows that in the hamster, immune susceptibility is affected by the magnitude and orientation of these agents (ie, IR, CYP) as they temporally relate to immunization and/or challenge with the antigen. Moreover, there is evidence that T‐independent as well as T‐dependent responses are affected by these treatments. Therefore, cyclophosphamide and irradiation modalities can be employed to modify the cellular immune responses in the hamster.