Alcohol Consumption and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer: The Life After Cancer Epidemiology Study
Alcohol Consumption and Breast Cancer Recurrence and Survival Among Women With Early-Stage Breast Cancer: The Life After Cancer Epidemiology Study
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DOI：
10.1200/jco.2010.29.2730
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发表时间：
2010-10-10
影响因子：
45.3
通讯作者：
Caan, Bette J.
中科院分区：
文献类型：
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作者：
Kwan, Marilyn L.;Kushi, Lawrence H.;Caan, Bette J.
目的研究乳腺癌诊断后饮酒与早期乳腺癌survivor.Patients和方法复发和死亡率之间的关系，患者包括1,897 LACE研究参与者1997年和2000年之间诊断为早期乳腺癌，平均2年后诊断，主要是从凯泽永久北方加州癌症登记。在进入队列时使用食物频率问卷评估酒精摄入量（即葡萄酒、啤酒和白酒）。考克斯比例风险模型被用来估计风险比（HR）和95%CI与已知的预后factors.Results调整293乳腺癌复发和273总死亡后，平均随访7.4年确定。958名妇女（51%）被认为是饮酒者（> 0.5克/天的酒精），大多数人喝葡萄酒（89%）。与不饮酒相比，饮酒≥ 6 g/d与乳腺癌复发（HR，1.35; 95% CI，1.00 - 1.83）和乳腺癌死亡（HR，1.51; 95% CI，1.00 - 2.29）风险增加相关。绝经后（HR，1.51; 95% CI，1.05 - 2.19）和超重和肥胖女性（HR，1.60; 95% CI，1.08 - 2.38）的复发风险增加似乎更大。酒精摄入量与全因死亡无关，并可能与非乳腺癌death.Conclusion的风险降低，每周消耗三至四个酒精饮料或更多的乳腺癌诊断后，可能会增加乳腺癌复发的风险，特别是在绝经后和超重/肥胖的妇女，但非乳腺癌死亡的心脏保护作用的酒精建议。J Clin Oncol 28：4410-4416. (c)2010年美国临床肿瘤学会
Purpose To examine the association of alcohol consumption after breast cancer diagnosis with recurrence and mortality among early-stage breast cancer survivors.Patients and Methods Patients included 1,897 LACE study participants diagnosed with early-stage breast cancer between 1997 and 2000 and recruited on average 2 years postdiagnosis, primarily from the Kaiser Permanente Northern California Cancer Registry. Alcohol consumption (ie, wine, beer, and liquor) was assessed at cohort entry using a food frequency questionnaire. Cox proportional hazards models were used to estimate hazard ratios (HR) and 95% CI with adjustment for known prognostic factors.Results Two hundred ninety-three breast cancer recurrences and 273 overall deaths were ascertained after an average follow-up of 7.4 years. Nine hundred fifty-eight women (51%) were considered drinkers (> 0.5 g/d of alcohol), and the majority drank wine (89%). Drinking >= 6 g/d of alcohol compared with no drinking was associated with an increased risk of breast cancer recurrence (HR, 1.35; 95% CI, 1.00 to 1.83) and death due to breast cancer (HR, 1.51; 95% CI, 1.00 to 2.29). The increased risk of recurrence appeared to be greater among postmenopausal (HR, 1.51; 95% CI, 1.05 to 2.19) and overweight and obese women (HR, 1.60; 95% CI, 1.08 to 2.38). Alcohol intake was not associated with all-cause death and possibly associated with decreased risk of non-breast cancer death.Conclusion Consuming three to four alcoholic drinks or more per week after a breast cancer diagnosis may increase risk of breast cancer recurrence, particularly among postmenopausal and overweight/obese women, yet the cardioprotective effects of alcohol on non-breast cancer death were suggested. J Clin Oncol 28:4410-4416. (c) 2010 by American Society of Clinical Oncology