Sleep characteristics that predict atrial fibrillation
Sleep characteristics that predict atrial fibrillation
复制标题
DOI：
10.1016/j.hrthm.2018.05.008
复制
发表时间：
2018-09-01
期刊：
影响因子：
5.5
通讯作者：
Marcus, Gregory M.
中科院分区：
文献类型：
--
作者：
Christensen, Matthew A.;Dixit, Shalini;Marcus, Gregory M.
睡眠中断与阻塞性睡眠呼吸暂停（OSA）和心房颤动（AF）之间的关系尚不清楚。目的：本研究的目的是确定睡眠不足本身是否是AF的危险因素。方法：我们首先对健康eHeart研究的参与者进行分析，并验证纵向心血管健康研究的结果，包括接受多导睡眠描记术的患者的子集。为了确定所观察到的关系是否容易转化为医疗实践，我们检查了2005-2009年的数据从加州医疗成本和利用Project.Results的4553健康eHeart参与者中，526与AF表现出更频繁的夜间觉醒（比值比[OR] 1.47; 95%置信区间[CI] 1.14-1.89; P = 0.003）。在5703名心血管健康研究参与者中，平均随访时间为11.6年，夜间频繁觉醒预测房颤风险增加33%（风险比[HR] 1.33; 95%CI 1.17-1.51; P
BACKGROUND The relationship between sleep disruption, independent of obstructive sleep apnea (OSA), and atrial fibrillation (AF) is unknown.OBJECTIVE The purpose of this study was to determine whether poor sleep itself is a risk factor for AF.METHODS We first performed an analysis of participants in the Health eHeart Study and validated those findings in the longitudinal Cardiovascular Health Study, including a subset of patients undergoing polysomnography. To determine whether the observed relationships readily translated to medical practice, we examined 2005-2009 data from the California Healthcare Cost and Utilization Project.RESULTS Among 4553 Health eHeart participants, the 526 with AF exhibited more frequent nighttime awakening (odd ratio [OR] 1.47; 95% confidence interval [CI] 1.14-1.89; P =.003). In 5703 Cardiovascular Health Study participants followed for a median 11.6 years, frequent nighttime awakening predicted a 33% greater risk of AF (hazard ratio [HR] 1.33; 95% CI 1.17-1.51; P