Exploratory assessment of perfluorinated compounds and human thyroid function
Exploratory assessment of perfluorinated compounds and human thyroid function
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DOI：
10.1016/j.physbeh.2009.02.005
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发表时间：
2010-02-09
影响因子：
2.9
通讯作者：
Vena, John E.
中科院分区：
文献类型：
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作者：
Bloom, Michael S.;Kannan, Kurunthachalam;Vena, John E.
甲状腺激素在人类神经发育和成人神经认知功能中起关键作用。持久性有机卤素污染物，如全氟化合物（PFCs），可能会干扰甲状腺的体内平衡，因此接触这些化合物可能是神经和认知异常的风险因素。在这项研究中，从纽约州的31名有执照的垂钓者中采集血清样本，分析了促甲状腺激素（TSH）、游离甲状腺素（FT 4）、全氟癸酸（PFDA）、全氟壬酸（PFNA）、全氟庚酸（PFHpA）、全氟己烷磺酸盐（PFHxS）、全氟辛酸（PFOA）、全氟辛烷磺酸盐（PFOS）、全氟辛烷磺酰胺（PFOSA）、和全氟十一烷酸（PFUnDA）。全氟辛烷磺酸和全氟CA的浓度最高，几何平均值分别为19.6纳克/毫升（95%可信区间16.3-23.5）和1.3纳克/毫升（95%可信区间1.2-1.5）。在一项横断面分析中，在α = 0.05时，未发现PFC或其总和与TSH或FT 4有统计学显著相关性。然而，事后把握度分析（尽管有限）表明，样本量适度增加至86例和129例受试者，可能有助于80%的把握度分别检测FT 4和PFDA（β =0.09）和PFUnDA（0=0.08）的统计学显著性相关性。运动鱼的消费可能有助于PFDA（r= 0.52，P=0.003）和PFUnDA（r = 0.40，P = 0.025）水平。这项初步研究并未表明非职业性全氟碳化物暴露与甲状腺功能之间存在关联。然而，FT 4与PFDA和PFUnDA（在低浓度下测量的PFCs）之间存在弱关联的可能性提高了。鉴于PFCs在环境中的普遍存在以及甲状腺功能对神经发育和神经认知终点的重要性，有必要进行验证性研究。(C)2009 Elsevier Inc. All rights reserved.
Thyroid hormones play critical roles in human neurodevelopment and adult neurocognitive function. Persistent organohalogen pollutants, such as perfluorinated compounds (PFCs), may interfere with thyroid homeostasis and thus exposures to these compounds might represent risk factors for neurologic and cognitive abnormalities. In this study, serum specimens collected from thirty-one licensed anglers in New York State were analyzed for levels of thyroid stimulating hormone (TSH), free thyroxine (FT4), perfluorodecanoic acid (PFDA), perfluorononanoic acid (PFNA), perfluoroheptanoic acid (PFHpA), perfluorohexanesulfonate (PFHxS), perfluorooctanoic acid (PFOA), perfluorooctanesulfonate (PFOS), perfluorooctanesulfonamide (PFOSA), and perfluoroundecanoic acid (PFUnDA). PFOS and PFCA occurred in the highest concentrations with geometric means of 19.6 ng/mL (95% CI 16.3-23.5) and 1.3 ng/mL (95% CI 1.2-1.5), respectively. In a cross-sectional analysis, no statistically significant associations were detected for PFCs, or their sum, with TSH or FT4 at alpha = 0.05. However, post hoc power analyses, though limited, suggested that moderate increases in sample size, to 86 and 129 subjects, might facilitate 80% power to detect statistically significant associations for FT4 and PFDA (beta=0.09) and PFUnDA (0=0.08), respectively. The consumption of sportfish may have contributed to PFDA (r=052, P=0.003) and PFUnDA (r = 0.40, P = 0.025) levels. This preliminary study does not indicate associations between non-occupational PFCs exposures and thyroid function. However, the possibility for weak associations for FT4 with PFDA and PFUnDA, PFCs measured in low concentrations, is raised. Given the ubiquity of PFCs in the environment and the importance of thyroid function to neurodevelopmental and neurocognitive endpoints, a confirmatory study is warranted. (C) 2009 Elsevier Inc. All rights reserved.