VISUALIZATION AND ANALYSIS OF MURAL THROMBOGENESIS ON COLLAGEN, POLYURETHANE AND NYLON
VISUALIZATION AND ANALYSIS OF MURAL THROMBOGENESIS ON COLLAGEN, POLYURETHANE AND NYLON
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DOI：
10.1016/0142-9612(86)90006-2
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发表时间：
1986-09-01
期刊：
影响因子：
14
通讯作者：
MCINTIRE, LV
中科院分区：
文献类型：
--
作者：
HUBBELL, JA;MCINTIRE, LV
Visualization and analysis of mural thrombogenesis on collagen-coated glass, polyurethane and nylon was discussed. Epi-fluorescent video microscopy was used to visualize thrombotic events at a protein or polymer surface in contact with flowing whole blood. Digital image processing was used to analyse the real-time microscopic images obtained, resulting in measurements of morphological features and the number of platelets that compose each thrombus. The three-dimensional structures of the thrombi were also estimated. A photodiode was used to measure integrated end-point platelet accumulation at different axial positions along the surface. Additionally, the convection-diffusion equations were solved to estimate the concentrations of adenosine diphosphate, thromboxane Az, and thrombin generated by activated platelets at the blood-contacting surface.
