Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study.
Combined berberine and probiotic treatment as an effective regimen for improving postprandial hyperlipidemia in type 2 diabetes patients: a double blinded placebo controlled randomized study.
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小檗碱和益生菌联合治疗作为改善 2 型糖尿病患者餐后高脂血症的有效方案：双盲安慰剂对照随机研究
DOI：
10.1080/19490976.2021.2003176
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发表时间：
2022-01
期刊：
影响因子：
12.2
通讯作者：
Wang W
中科院分区：
文献类型：
--
作者：
Wang S;Ren H;Zhong H;Zhao X;Li C;Ma J;Gu X;Xue Y;Huang S;Yang J;Chen L;Chen G;Qu S;Liang J;Qin L;Huang Q;Peng Y;Li Q;Wang X;Zou Y;Shi Z;Li X;Li T;Yang H;Lai S;Xu G;Li J;Zhang Y;Gu Y;Wang W
摘要非空腹脂血症(NFL)主要由餐后脂血症(PL)引起，近年来被认为是与空腹脂血症(FL)一样的心血管疾病(CVD)的重要危险因素。PL是2型糖尿病(T2D)患者血脂异常的共同特征，尽管针对PL的有效治疗方法有限。在本研究中，我们旨在评价益生菌(PROB)和黄连素(BBR)联合治疗是否能有效降低T2D中的PL，并探讨其可能的机制。采用随机、安慰剂对照的多中心临床试验，对365名服用益生菌和BBR的受试者在服用100g标准碳水化合物餐后120min的血PL进行了检测，以了解益生菌和BBR对新诊断的2型糖尿病患者肠道菌群的疗效和变化。PROB+BBR在改善餐后总胆固醇(PTC)和低密度脂蛋白胆固醇(PLDLc)方面优于BBR或单用PROB，3个月后多组餐后脂代谢产物减少。这一效应与BBR单独处理或PROB+BBR处理引起的粪便双歧杆菌短水平的变化有关。在该菌株基因组中发现了4个编码长链酰辅酶A合成酶的FADD基因，并被BBR转录激活。在体外，BBR处理进一步降低了B.breve培养基中的FFA浓度。因此，BBR激活FADD可以促进短杆菌FFA的输入和动员，并稀释腔内脂质的吸收，从而介导PROB+BBR对PL的影响。我们的研究证实，BBR和Prob(B.breve)对PL具有协同降脂作用，在T2D中作为肠道脂质汇达到更好的血脂水平和心血管风险控制。
ABSTRACT Non-fasting lipidemia (nFL), mainly contributed by postprandial lipidemia (PL), has recently been recognized as an important cardiovascular disease (CVD) risk as fasting lipidemia (FL). PL serves as a common feature of dyslipidemia in Type 2 Diabetes (T2D), albeit effective therapies targeting on PL were limited. In this study, we aimed to evaluate whether the therapy combining probiotics (Prob) and berberine (BBR), a proven antidiabetic and hypolipidemic regimen via altering gut microbiome, could effectively reduce PL in T2D and to explore the underlying mechanism. Blood PL (120 min after taking 100 g standard carbohydrate meal) was examined in 365 participants with T2D from the Probiotics and BBR on the Efficacy and Change of Gut Microbiota in Patients with Newly Diagnosed Type 2 Diabetes (PREMOTE study), a random, placebo-controlled, and multicenter clinical trial. Prob+BBR was superior to BBR or Prob alone in improving postprandial total cholesterol (pTC) and low-density lipoprotein cholesterol (pLDLc) levels with decrement of multiple species of postprandial lipidomic metabolites after 3 months follow-up. This effect was linked to the changes of fecal Bifidobacterium breve level responding to BBR alone or Prob+BBR treatment. Four fadD genes encoding long-chain acyl-CoA synthetase were identified in the genome of this B. breve strain, and transcriptionally activated by BBR. In vitro BBR treatment further decreased the concentration of FFA in the culture medium of B. breve compared to vehicle. Thus, the activation of fadD by BBR could enhance FFA import and mobilization in B. breve and diliminish the intraluminal lipids for absorption to mediate the effect of Prob+BBR on PL. Our study confirmed that BBR and Prob (B. breve) could exert a synergistic hypolipidemic effect on PL, acting as a gut lipid sink to achieve better lipidemia and CVD risk control in T2D.
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DOI：
10.5114/aoms.2017.69326
发表时间：
2017-08
期刊：
Archives of medical science : AMS
影响因子：
--
作者：
Cicero AFG;Colletti A;Bajraktari G;Descamps O;Djuric DM;Ezhov M;Fras Z;Katsiki N;Langlois M;Latkovskis G;Panagiotakos DB;Paragh G;Mikhailidis DP;Mitchenko O;Paulweber B;Pella D;Pitsavos C;Reiner Ž;Ray KK;Rizzo M;Sahebkar A;Serban MC;Sperling LS;Toth PP;Vinereanu D;Vrablík M;Wong ND;Banach M
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Banach M
影响因子：
30.3
作者：
Araujo, Joao R.;Tazi, Asmaa;Sansonetti, Philippe J.
通讯作者：
Sansonetti, Philippe J.
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5.3
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Bozzetto, Lutgarda;Annuzzi, Giovanni;Rivellese, Angela A.
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Rivellese, Angela A.
影响因子：
37.8
作者：
Doran, Bethany;Guo, Yu;Bangalore, Sripal
通讯作者：
Bangalore, Sripal
影响因子：
20.1
作者：
Fu J;Bonder MJ;Cenit MC;Tigchelaar EF;Maatman A;Dekens JA;Brandsma E;Marczynska J;Imhann F;Weersma RK;Franke L;Poon TW;Xavier RJ;Gevers D;Hofker MH;Wijmenga C;Zhernakova A
通讯作者：
Zhernakova A