Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.
Identification of the region of T cell receptor beta chain that interacts with the self-superantigen MIs-1a.
复制标题
鉴定与自身超抗原 MIs-1a 相互作用的 T 细胞受体 β 链区域。
DOI：
10.1016/0092-8674(90)90700-o
复制
发表时间：
1990
期刊：
影响因子：
64.5
通讯作者：
Kappler,JW
中科院分区：
文献类型：
--
作者：
Pullen,AM;Wade,T;Marrack,P;Kappler,JW
Superantigen-MHC complexes are known to stimulate T cells primarily via the Vp element of the T cell receptor. In this paper we identify a number of amino acid residues that define the region of a particular Vp element interacting with one of the self-superantigens, MIS-la. These residues are predicted to lie on a b-pleated sheet of the T cell receptor, away from the complementarity determining regions of the receptor, which are thought to interact with complexes of conventional peptide antigens and MHC. In support of this prediction, mutations affecting MIS-la activity have no effect on the response to conventional antigen and MHC.
