Ruthenium-catalyzed cycloisomerization of 1,3-dienes, for example, an N-dienyl-2-vinylaniline derivative, leading to a 3-Exomethylene-2-vinylindole derivative and its application to the synthesis of (±)-cinchonaminone
Ruthenium-catalyzed cycloisomerization of 1,3-dienes, for example, an N-dienyl-2-vinylaniline derivative, leading to a 3-Exomethylene-2-vinylindole derivative and its application to the synthesis of (±)-cinchonaminone
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钌催化的 1,3-二烯环异构化，例如 N-二烯基-2-乙烯基苯胺衍生物，产生 3-外亚甲基-2-乙烯基吲哚衍生物及其在 (±)-辛可那胺合成中的应用
DOI：
10.1002/ejoc.201200260
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发表时间：
2012
期刊：
影响因子：
--
通讯作者：
Takao Ogawa
中科院分区：
文献类型：
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作者：
鈴木悠;山崎俊正;朝倉哲郎;小林優美;瀧宮和男;Takao Ogawa
Ru催化的1，3-二烯和N-二烯基-2-乙烯基苯胺底物的烯烃的环异构化顺利进行，以良好的产率产生3-外亚甲基-2-乙烯基吲哚衍生物。该合成子已成功应用于（±）-辛可胺酮的全合成。
Ru‐catalyzed cycloisomerization of a 1,3‐diene and the alkene of anN‐dienyl‐2‐vinylaniline substrate proceeded smoothly, leading to a 3‐exomethylene‐2‐vinylindole derivative in good yield. This useful synthon was successfully applied to the total synthesis of (±)‐cinchonaminone.