Regulation of Nucleo-Cytoplasmic Transport of the Aryl Hydrocarbon Receptor
Regulation of Nucleo-Cytoplasmic Transport of the Aryl Hydrocarbon Receptor
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DOI：
10.1248/jhs.50.215
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发表时间：
2004-06
影响因子：
--
通讯作者：
K. Kawajiri;T. Ikuta
中科院分区：
文献类型：
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作者：
K. Kawajiri;T. Ikuta
芳烃受体 (AhR) 是一种配体激活的转录因子，在异生物质信号通路的细胞内介质中发挥作用。 AhR 是一种由核定位信号 (NLS) 和核输出信号 (NES) 介导的核质穿梭蛋白。蛋白激酶 C 介导的 NLS 磷酸化抑制 AhR 配体依赖性核输入，表明核输入的两步机制。由于核输出活性的调节，细胞密度调节 AhR 细胞内定位。 p38 丝裂原激活蛋白激酶 (MAPK) 介导的 NES 磷酸化及其去磷酸化（受细胞接触信号调节）可能在新型 AhR 重新定位中发挥关键作用。
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcription factor that plays a role as an intracellular mediator of the xenobiotic signaling pathway. AhR is a nucleo-cytoplasmic shuttling protein mediated by nuclear localization signals (NLS) and nuclear export signals (NES). Protein kinase C-mediated phosphorylation of NLS inhibits the ligand-dependent nuclear import of AhR, suggesting a two-step mechanism of nuclear import. Cell density regulates AhR intracellular localization, due to modulation of nuclear export activity. The p38 mitogenactivated protein kinase (MAPK)-mediated phosphorylation of NES and its dephosphorylation, regulated by cellcell contact signals, may have pivotal roles in the novel AhR relocalization.