Electrophysiological mechanisms underlying hypoxia-induced deficits in visual spatial and non-spatial discrimination.
Electrophysiological mechanisms underlying hypoxia-induced deficits in visual spatial and non-spatial discrimination.
复制标题
缺氧引起的视觉空间和非空间辨别缺陷的电生理机制
DOI：
10.14814/phy2.15036
复制
发表时间：
2021-09
影响因子：
2.5
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Qiu Q;Lv P;Zhongshen Y;Yuan F;Zhang X;Zhou X;Li S;Liu X;Zhang J
低氧环境下居民的视觉认知功能受损已被广泛报道，但其潜在的电生理机制尚不清楚。在这项研究中，23名大学生在30天的高海拔暴露前（测试1）和返回低地后1周（测试2）和3个月（测试3）进行了三次时钟任务测试。时钟任务由视觉空间角度和视觉非空间颜色辨别子任务组成。同时，在时钟任务期间记录脑电图（EEG）。行为学结果表明，与实验1相比，实验2中被试在角度和颜色两个任务上的准确率显著降低，而在角度任务上的反应时显著增加。事件相关电位结果显示，与测试1相比，在两项任务期间，测试2中两项任务期间枕叶N1和P3分量的振幅均显著降低。N1波幅与反应时呈负相关，与准确性呈正相关。进一步的时间-频率EEG分析表明，θ功率在枕部网站显着下降，在这两个任务中，在测试2，与测试1相比，并与RT的角度任务呈负相关。在测试3中，行为表现和EEG活动都恢复到测试1的基线水平。这些发现表明，缺氧损害视觉空间和视觉非空间辨别，并且这些损害可以在受试者返回低地后恢复。视觉皮层的脑电生理活动受到抑制可以解释视觉认知的缺陷。高原视觉认知的首次纵向电生理研究。HA暴露后，视觉空间和视觉非空间能力均受损。视觉皮层中事件相关电位N1和P3的抑制解释了视觉障碍。
Impaired visual cognition in residents of hypoxic environment has been widely reported; however, the underlying electrophysiological mechanisms remain unclear. In this study, 23 college students underwent three sessions of a Clock task test before a 30‐day high‐altitude exposure (Test 1) and 1 week (Test 2) and 3 months (Test 3) after they returned to lowlands. The Clock task consists of a visual spatial angle and a visual non‐spatial color discrimination subtask. Simultaneously, electroencephalography (EEG) was recorded during the Clock task. The behavioral results showed that, compared with Test 1, accuracy in Test 2 was significantly decreased in both the Angle and Color tasks, and reaction time (RT) was significantly increased in the Angle task. The event‐related potentials results showed that, during both tasks amplitudes of the occipital N1 and P3 components during both tasks were significantly decreased in Test 2, compared with Test 1. Moreover, N1 amplitude was negatively correlated with RT and positively correlated with accuracy. Further time–frequency EEG analysis showed that theta power at occipital sites was significantly decreased in both tasks in Test 2, compared with Test 1, and was negatively correlated with RT in the Angle task. In Test 3, both the behavioral performance and EEG activity recovered to the baseline level in Test 1. These findings suggested that hypoxia impairs both visual spatial and visual non‐spatial discriminations, and these impairments can recover after subjects return to lowlands. Inhibition of brain electrophysiological activity in the visual cortex may explain the deficits in visual cognition. A first longitudinal electrophysiological study for high altitude (HA) visual cognitions. Both visual spatial and visual non‐spatial abilities impaired after HA exposure. Inhibition of event‐related potential N1 and P3 in visual cortex explains the visual impairment.