ASSOCIATION OF CORONARY ATHEROSCLEROSIS WITH HYPERAPOBETA-LIPOPROTEINEMIA [INCREASED PROTEIN BUT NORMAL CHOLESTEROL LEVELS IN HUMAN-PLASMA LOW-DENSITY (BETA)-LIPOPROTEINS]
ASSOCIATION OF CORONARY ATHEROSCLEROSIS WITH HYPERAPOBETA-LIPOPROTEINEMIA [INCREASED PROTEIN BUT NORMAL CHOLESTEROL LEVELS IN HUMAN-PLASMA LOW-DENSITY (BETA)-LIPOPROTEINS]
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DOI：
10.1073/pnas.77.1.604
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发表时间：
1980-01-01
期刊：
影响因子：
--
通讯作者：
KWITEROVICH, PO
中科院分区：
文献类型：
--
作者：
SNIDERMAN, A;SHAPIRO, S;KWITEROVICH, PO
大多数冠状动脉疾病患者的血浆或低密度脂蛋白（LDL）胆固醇并不升高。为探讨低密度脂蛋白（LDL）的蛋白质部分--低密度脂蛋白（B）是否可作为鉴别缺血性心脏病的一个参数，对100例连续心导管检查患者的血浆胆固醇、甘油三酯、LDL胆固醇和LDL B进行了测定。根据冠状动脉造影结果将患者分为两组：I组31例无冠状动脉病变，II组59例有明显冠状动脉病变。虽然胆固醇，甘油三酯和LDL胆固醇水平均显着高于组II判别分析表明，LDL B浓度最清楚地分开2组。在I组（非冠状动脉）中，LDL B为82 . ±-。22 mg/100 ml，而在组II中，LDL B为118 ± 0.05。22 mg/100 ml。组I中的B蛋白水平与所研究的其他正常组相似（35名无症状男性医生，83 ± 100。11 mg/100 ml，90名血脂正常的医学生，72 . ±. 17 mg/100 ml）。LDL B明显比其他研究的血脂参数更好地区分冠状动脉组和非冠状动脉组，在冠状动脉疾病患者中，存在一组LDL胆固醇正常，但LDL B蛋白水平与II型高脂蛋白血症相似。在该组中观察到的LDL成分改变仍有待解释。
Most patients with coronary artery disease do not have elevated plasma or low density lipoprotein (LDL) cholesterol. To test whether the protein moiety of LDL, LDL B, might be a parameter to identify ischemic heart disease the plasma cholesterol, triglyceride, LDL cholesterol and LDL B were measured in 100 consecutive patients undergoing cardiac catheterization. On the basis of coronary angiography these patients were divided into 2 groups: group I, 31 patients without, and group II, 59 patients with significant coronary artery disease. Although cholesterol, triglyceride and LDL cholesterol levels were all significantly higher in group II discriminant analysis indicated that LDL B concentrations most clearly separated the 2 groups. In group I (noncoronary) LDL B was 82 .+-. 22 mg/100 ml whereas in group II, LDL B was 118 .+-. 22 mg/100 ml. The B protein level in group I was similar to other normal groups studied (35 asymptomatic male physicians, 83 .+-. 11 mg/100 ml and 90 normolipidemic medical students, 72 .+-. 17 mg/100 ml). LDL B apparently better separates coronary and noncoronary groups than other lipid parameters studied and among those with coronary artery disease, there exists a group with normal LDL cholesterol but with levels of LDL B protein similar to those observed in type II hyperlipoproteinemia. The altered LDL composition observed in this group remains to be explained.