Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis.
Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis.
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白细胞和血小板纤维蛋白的再生潜力。 A部分：骨内缺陷，毛囊缺陷和牙周整形手术。系统评价和荟萃分析。
DOI：
10.1111/jcpe.12643
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发表时间：
2017-01
影响因子：
6.7
通讯作者：
Quirynen M
中科院分区：
文献类型：
--
作者：
Castro AB;Meschi N;Temmerman A;Pinto N;Lambrechts P;Teughels W;Quirynen M
分析牙周手术中富含白细胞和血小板的纤维蛋白（L - PRF）的再生潜力。在三个数据库中进行了电子和手工搜索。只选择随机临床试验，没有随访限制。牙袋深度（PD）、临床附着水平（CAL）、骨填充、角化组织宽度（KTW）、退行性减少和牙根覆盖率（%）被视为结果。在可能的情况下，进行meta分析。24篇文章符合纳入和排除标准。三个亚组被创建：骨内缺损（IBDs），分叉缺损和牙周整形手术。对所有亚组进行Meta分析。L - PRF与开放式皮瓣清创（OFD）相比，PD降低（1.1±0.5 mm, p < 0.001）、CAL增加（1.2±0.6 mm, p < 0.001）和骨填充（1.7±0.7 mm, p < 0.001）显著。对于功能性缺损，L - PRF与OFD相比，PD减少（1.9±1.5 mm, p = 0.01）， CAL增加（1.3±0.4 mm, p < 0.001）和骨填充（1.5±0.3 mm, p < 0.001）显著。当L‐PRF与结缔组织移植物比较时，PD减少（0.2±0.3 mm, p > 0.05）， CAL增加（0.2±0.5 mm, p > 0.05）， KTW（0.3±0.4 mm, p > 0.05）和退缩减少（0.2±0.3 mm, p > 0.05）的结果相似。L‐PRF促进牙周伤口愈合。
To analyse the regenerative potential of leucocyte‐ and platelet‐rich fibrin (L‐PRF) during periodontal surgery. An electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow‐up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta‐analysis was performed. Twenty‐four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra‐bony defects (IBDs), furcation defects and periodontal plastic surgery. Meta‐analysis was performed in all the subgroups. Significant PD reduction (1.1 ± 0.5 mm, p < 0.001), CAL gain (1.2 ± 0.6 mm, p < 0.001) and bone fill (1.7 ± 0.7 mm, p < 0.001) were found when comparing L‐PRF to open flap debridement (OFD) in IBDs. For furcation defects, significant PD reduction (1.9 ± 1.5 mm, p = 0.01), CAL gain (1.3 ± 0.4 mm, p < 0.001) and bone fill (1.5 ± 0.3 mm, p < 0.001) were reported when comparing L‐PRF to OFD. When L‐PRF was compared to a connective tissue graft, similar outcomes were recorded for PD reduction (0.2 ± 0.3 mm, p > 0.05), CAL gain (0.2 ± 0.5 mm, p > 0.05), KTW (0.3 ± 0.4 mm, p > 0.05) and recession reduction (0.2 ± 0.3 mm, p > 0.05). L‐PRF enhances periodontal wound healing.