OPTIMUM EXPERIMENTAL-DESIGNS FOR PROPERTIES OF A COMPARTMENTAL MODEL
OPTIMUM EXPERIMENTAL-DESIGNS FOR PROPERTIES OF A COMPARTMENTAL MODEL
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DOI：
10.2307/2532547
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发表时间：
1993-06-01
期刊：
影响因子：
1.9
通讯作者：
JURITZ, J
中科院分区：
文献类型：
--
作者：
ATKINSON, AC;CHALONER, K;JURITZ, J
在使用房室模型的生物利用度研究中，三个感兴趣的特性是浓度曲线下面积、最大浓度和达到最大浓度的时间。描述了用于寻找使此类模型中这些量的估计方差最小化的设计的方法。这些方法使用先验信息。使用先验估计和先验分布。对于所有参数，将开放一室模型的设计与相应的D（θ）最优设计进行比较，并与最小化单个属性的缩放方差之和的设计进行比较。
Three properties of interest in bioavailability studies using compartmental models are the area under the concentration curve, the maximum concentration, and the time to maximum concentration. Methods are described for finding designs that minimize the variance of the estimates of these quantities in such a model. These methods use prior information. Both prior estimates and prior distributions are used. The designs for an open one-compartment model are compared with the corresponding D(theta)-optimum design for all parameters and also with designs that minimize the sum of the scaled variances of the individual properties.