Continued maturation of the click-evoked auditory brainstem response in preschoolers.
Continued maturation of the click-evoked auditory brainstem response in preschoolers.
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DOI：
10.3766/jaaa.26.1.4
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发表时间：
2015-01
影响因子：
1.2
通讯作者：
Kraus N
中科院分区：
文献类型：
--
作者：
Spitzer E;White-Schwoch T;Carr KW;Skoe E;Kraus N
短声诱发的听觉脑干反应（ABR）是研究听觉系统功能和发育的重要工具。虽然长期以来人们一直认为人类听觉脑干在2岁时就已经完全成熟，但最近的证据表明，听觉脑干的发育轨迹是长期的。本研究的目的是确定在学龄前人群的ABR成熟的时间过程，并填补了知识的发展的差距。使用横断面设计，我们调查了年龄对绝对潜伏期，波间潜伏期和振幅（波I，III，V）的点击诱发ABR的影响。共有71名学龄前儿童（年龄3.12-4.99岁）参与了这项研究。所有患者的外周听觉功能和智商均正常。当参与者坐着看电影时，使用临床标准记录和过滤程序单耳记录以31/秒和80 dB SPL（73 dB nHL）呈现的稀疏点击刺激的ABR。绝对潜伏期、波间潜伏期和振幅与年龄相关。发育变化仅限于绝对乳量。波V潜伏期随着年龄的增长显着下降，而波I和III潜伏期保持稳定，即使在这个有限的年龄范围。ABR在2岁后并不保持静止，如3岁至5岁之间V波潜伏期的系统性降低所示。这一发现表明，人类脑干在学龄前有一个持续的发育时间过程。当使用ABR作为听力健康的指标时，应考虑3-5岁年龄范围内的潜伏期变化。
Click-evoked auditory brainstem responses (ABRs) are a valuable tool for probing auditory system function and development. Although it has long been thought that the human auditory brainstem is fully mature by age 2 yr, recent evidence indicates a prolonged developmental trajectory. The purpose of this study was to determine the time course of ABR maturation in a preschool population and fill a gap in the knowledge of development. Using a cross-sectional design, we investigated the effect of age on absolute latencies, interwave latencies, and amplitudes (waves I, III, V) of the click-evoked ABR. A total of 71 preschoolers (ages 3.12–4.99 yr) participated in the study. All had normal peripheral auditory function and IQ. ABRs to a rarefaction click stimulus presented at 31/sec and 80 dB SPL (73 dB nHL) were recorded monaurally using clinically-standard recording and filtering procedures while the participant sat watching a movie. Absolute latencies, interwave latencies, and amplitudes were then correlated to age. Developmental changes were restricted to absolute latencies. Wave V latency decreased significantly with age, whereas wave I and III latencies remained stable, even in this restricted age range. The ABR does not remain static after age 2 yr, as seen by a systematic decrease in wave V latency between ages 3 and 5 yr. This finding suggests that the human brainstem has a continued developmental time course during the preschool years. Latency changes in the age 3–5 yr range should be considered when using ABRs as a metric of hearing health.