Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood.
Body mass index and physical activity in early childhood are associated with atopic sensitization, atopic dermatitis and asthma in later childhood.
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DOI：
10.1186/s13601-016-0124-9
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发表时间：
2016
影响因子：
4.4
通讯作者：
Øymar K
中科院分区：
文献类型：
--
作者：
Byberg KK;Eide GE;Forman MR;Júlíusson PB;Øymar K
关于儿童期超重/肥胖和体力活动与特应性致敏和特应性疾病之间关系的研究结果并不一致。我们研究了儿童期人体测量学和体力活动与儿童后期特应性致敏和特应性疾病的关系。在一项队列研究中，包括在怀孕期间暴露于先兆子痫的病例和对照组，对617名儿童在几个年龄段的人体测量和体力活动进行了评估。使用多元逻辑回归分析与儿童后期特应性致敏和特应性疾病的关系。1年时的体重指数标准差评分（BMI SDS）和3-6年时的低体力活动与12.8年时的特应性致敏呈正相关[校正比值比（OR）分别为1.22; 95%置信区间（1.00，1.49）和OR 2.36;（1.15，4.81）]。1 - 4年BMI SDS、4年BMI SDS和6-10年高体力活动的变化与特应性皮炎10.8年呈正相关[分别为OR 1.46;（1.11，1.92）; OR 1.32;（1.06，1.65）和OR 1.94;（1.16，3.24）]。3-6岁和6-10岁的低体力活动与10.8岁的哮喘呈正相关[OR分别为3.61;（1.56，8.36）和OR 2.52;（1.24，5.12）]。儿童早期的BMI和体力活动与儿童后期的特应性致敏、特应性皮炎和哮喘相关。为了进一步阐明这一问题，需要对预测因子和结局进行重复测量的更大队列。试验注册我们的研究是观察性的，对参与者没有任何临床干预。本文的在线版本（doi：10.1186/s13601-016-0124-9）包含补充材料，可供授权用户使用。
The results of studies on the associations of childhood excessive weight/obesity and physical activity with atopic sensitization and atopic diseases are inconsistent. We studied the associations of anthropometry and physical activity in childhood with atopic sensitization and atopic diseases in late childhood. In a cohort study including cases exposed to preeclampsia during pregnancy and controls, anthropometry and physical activity were assessed at several ages in 617 children. Associations with atopic sensitization and atopic diseases in late childhood were analysed using multiple logistic regression. Body mass index standard deviation score (BMI SDS) at 1 year and low physical activity at 3–6 years were positively associated with atopic sensitization at 12.8 years [adjusted odds ratio (OR) 1.22; 95 % confidence interval (1.00, 1.49) and OR 2.36; (1.15, 4.81), respectively]. Change in BMI SDS from 1 to 4 years, BMI SDS at 4 years, and high physical activity at 6–10 years were positively associated with atopic dermatitis by 10.8 years [OR 1.46; (1.11, 1.92); OR 1.32; (1.06, 1.65) and OR 1.94; (1.16, 3.24); respectively]. Low physical activity at 3–6 and 6–10 years were positively associated with asthma by 10.8 years [OR 3.61; (1.56, 8.36) and OR 2.52; (1.24, 5.12), respectively]. BMI and physical activity in early childhood were associated with atopic sensitization, atopic dermatitis and asthma in later childhood. Larger cohorts with repeated measurements of both predictors and outcomes are required to further elucidate this issue. Trial registration Our study was observational without any clinical intervention on the participants. Therefore, no trial registration number is available The online version of this article (doi:10.1186/s13601-016-0124-9) contains supplementary material, which is available to authorized users.
影响因子：
4.5
作者：
Nova E;Martínez-Gómez D;Gómez-Martínez S;Veses AM;Calle ME;Veiga OL;Marcos A
通讯作者：
Marcos A