The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder.
The effect of nefazodone on subjective and objective sleep quality in posttraumatic stress disorder.
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DOI：
10.4088/jcp.v64n0415
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发表时间：
2003-04
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影响因子：
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通讯作者：
T. Neylan;M. Lenoci;M. Maglione;N. Rosenlicht;Y. Leykin;T. Metzler;F. Schoenfeld;C. Marmar
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文献类型：
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作者：
T. Neylan;M. Lenoci;M. Maglione;N. Rosenlicht;Y. Leykin;T. Metzler;F. Schoenfeld;C. Marmar
本研究评估奈法唑酮治疗（目标剂量为400-600 mg/天）对患有慢性创伤后应激障碍（PTSD）的越南作战退伍军人的客观和主观睡眠质量的疗效。方法医学健康的男性越南战区作战退伍军人与DSM-IV PTSD（N = 10）完成了为期12周的开放标签试验。在基线和试验结束时获得两个晚上的动态多导睡眠图。在基线和12周后评估PTSD和抑郁症状以及主观睡眠质量。数据是在1999年和2000年收集的。结果奈法唑酮治疗导致PTSD和抑郁症状显著减少（p <0.05），整体主观睡眠质量改善，噩梦减少。奈法唑酮还导致睡眠质量客观指标的显著改善，特别是通过周期振幅分析测量的总睡眠时间、睡眠维持和δ睡眠增加。结论奈法唑酮治疗能改善创伤后应激障碍患者的主观和客观睡眠质量。
BACKGROUND This study assesses the efficacy of nefazodone treatment (target dose of 400-600 mg/day) on objective and subjective sleep quality in Vietnam combat veterans with chronic DSM-IV posttraumatic stress disorder (PTSD). METHOD Medically healthy male Vietnam theater combat veterans with DSM-IV PTSD (N = 10) completed a 12-week open-label trial. Two nights of ambulatory polysomnography were obtained at baseline and at the end of the trial. PTSD and depressive symptoms and subjective sleep quality were assessed at baseline and after 12 weeks. Data were collected in 1999 and 2000. RESULTS Nefazodone treatment led to a significant decrease in PTSD and depressive symptoms (p <.05), an improvement in global subjective sleep quality, and a reduction in nightmares. Nefazodone also resulted in a substantial improvement in objective measures of sleep quality, particularly increased total sleep time, sleep maintenance, and delta sleep as measured by period amplitude analysis. CONCLUSION Nefazodone therapy results in an improvement of both subjective and objective sleep quality in subjects with combat-related PTSD.