Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
Pigment patterns in adult fish result from superimposition of two largely independent pigmentation mechanisms
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DOI：
10.1111/pcmr.12335
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发表时间：
2015-03-01
影响因子：
4.3
通讯作者：
Rotllant, Josep
中科院分区：
文献类型：
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作者：
Ceinos, Rosa M.;Guillot, Raul;Rotllant, Josep
背腹色素模式差异是脊椎动物中最普遍的色素适应。在哺乳动物中，这种模式是通过使用蛋白质刺鼠信号肽（ASIP）调节黑素细胞中的黑色素化学来控制的。在鱼类中，色素图案的研究主要集中在条纹的形成上，确定了依赖于不同色素细胞类型之间相互作用的核心条纹机制。相反，驱动背腹反阴影模式的机制却被忽视了。在这里，我们证明，事实上，斑马鱼利用两种不同的成体色素图案机制——一种古老的背腹图案机制，以及一种基于细胞间相互作用的较新的条纹机制；值得注意的是，背腹模式机制也利用了 ASIP。这两种机制在很大程度上独立运作，所产生的模式叠加以给出完整的模式。
Dorso-ventral pigment pattern differences are the most widespread pigmentary adaptations in vertebrates. In mammals, this pattern is controlled by regulating melanin chemistry in melanocytes using a protein, agoutisignalling peptide (ASIP). In fish, studies of pigment patterning have focused on stripe formation, identifying a core striping mechanism dependent upon interactions between different pigment cell types. In contrast, mechanisms driving the dorso-ventral countershading pattern have been overlooked. Here, we demonstrate that, in fact, zebrafish utilize two distinct adult pigment patterning mechanisms -an ancient dorso-ventral patterning mechanism, and a more recent striping mechanism based on cell-cell interactions; remarkably, the dorso-ventral patterning mechanism also utilizes ASIP. These two mechanisms function largely independently, with resultant patterns superimposed to give the full pattern.